The study on assessing the impacts of saline intrusion on water resources, from building a hydraulic model MIKE 11 including hydraulic model, rain model, and advection–dispersion module (HD + RR + AD) together with the calculation scenarios in consideration of climate change through the high scenarios RCP 8.5 and low scenarios RCP 4.5 in 2025, 2030 and 2050 are highlighted in the paper. In addition, the impacts of salinity, salinity margins on the constructions, and water resources through the cases with or without the saltwater prevention works are considered, thereby assessing the impact of salinity intrusion through scenarios and structural solutions for water resources in HCMC.