Khảo sát hoạt tính kháng Candida albicans của phối hợp cao Trầu không (Piper betle L. Piperaceae) và tinh dầu Bách lí hương (Thymus vulgaris L. Lamiaceae)

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Tác giả: Yến Nhi Ngô, Thị Bạch Tuyết Nguyễn, Bền Chí Phạm, Thúy Hường Phạm, Kim Thái Phan

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Nguyễn Tất Thành, 2022

Mô tả vật lý: tr.55

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ID: 331054

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Betel extract contains Hydroxychavicol which inhibits the growth of Candida albicans through inhibition of DNA replication. Thyme essential oil was reported about anti – Candidal activity. Its mechanism of action involves the inhibition of ergosterol biosynthesis in the cell membrane. Based on the principle of the combination of two agents that have different mechanisms of action in the treatment of infection, the study was conducted to evaluate the efficacy against C. albicans of the combination of betel extract and thyme essential oil. The results indicated that the combination of betel extract and thyme essential oil (ratio of 1 mg : 4 μL) synergistically interacted on inhibiting C. albicans ATCC 10231 in vitro and ex vivo models of permeability through nail. Besides, by ex vivo infected nail model, the research showed that the combination of betel extract 0.156 % (w/v) and thyme essential oil 0.625 % (v/v) killed the fungi. The results could provide basic information to develop some preparations (cream, gel, etc) that contain betel extract and thyme essential oil for the treatment of onychomycosis.Cao Trầu không chứa hoạt chất hydroxychavicol có khả năng ức chế sự phát triển của Candida albicans thông qua quá trình ức chế quá trình nhân đôi DNA. Tinh dầu Bách lí hương đã được báo cáo kháng Candida spp. Cơ chế tác động của nó là ức chế quá trình sinh tổng hợp ergosterol trên màng tế bào. Dựa trên nguyên tắc phối hợp 2 chất có cơ chế tác động khác nhau trong điều trị bệnh nhiễm trùng, nhóm tác giả tiến hành khảo sát hiệu quả kháng C. albicans ATCC 10231 của phối hợp cao Trầu không và tinh dầu Bách lí hương. Kết quả cho thấy phối hợp cao Trầu không – tinh dầu Bách lí hương (1 mg : 4 μL) có hiệu quả cộng lực kháng C. abicans trên mô hình in vitro và mô hình tính thấm qua móng ex vivo. Đồng thời, bằng mô hình gây nhiễm móng ex vivo, nghiên cứu cũng đã xác định được phối hợp cao Trầu không 0,156 % (w/v) và tinh dầu Bách lí hương 0,625 % (v/v) có khả năng diệt nấm C. albicans ATCC 10231. Các kết quả này tạo tiền đề để phát triển công thức các dạng bào chế (kem, gel,…) hỗ trợ điều trị bệnh nấm móng Candida chứa cao Trầu không và tinh dầu Bách lí hương.

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