Đánh giá khả năng bảo hộ của một số loại vacxin cúm gia cầm sử dụng cho gà và vịt chống lại virus cúm A/H5N6 CLADE 2.3.4B phân lập năm 2016

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Tác giả: Văn Lâm Nguyễn, Long Thành Tô

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học kỹ thuật Thú y, 2020

Mô tả vật lý: tr.36

Bộ sưu tập: Metadata

ID: 331134

Thêm vào giỏ Liên kết toàn văn

The experiment was performed on chickens and ducks to evaluate the protection of Navetvifluvac and Re-5 vaccines against clade 2.3.4.4b A/H5N6 influenza virus isolated in 2016. The experimental results showed that Navet-vifluvac vaccine was able to stimulate antibody response with HI titer of 5.4 log2 in chickens (1 injection) and 8.3 log2 in ducks (2 injections)
meanwhile, chickens had a HI antibody response with a titre of 6.7 log2 and ducks with a titre of 8.7 log2 when receiving Re-5 vaccination. The virulent challenge by clade 2.3.4.4b A/H5N6 influenza virus showed that Navet-vifluvac vaccine protected 80% of the vaccinated chickens and 100% of the vaccinated ducks
while the Re-5 vaccine protected 70% of the vaccinated chickens and 100% of the vaccinated ducks. Both vaccines have the effect of significantly reducing the amount of virus excreted from the vaccinated chickens and ducks when compared with animals that was not vaccinated.Thí nghiệm đã được thực hiện trên gà và vịt để đánh giá khả năng bảo hộ của vacxin Navetvifluvac và vacxin Re-5 chống lại virus cúm A/H5N6 clade 2.3.4.4b phân lập năm 2016. Kết quả thí nghiệm cho thấy vacxin Navet-vifluvac có khả năng kích thích tạo kháng thể với hiệu giá HI là 5,4 log2ở gà (tiêm 1 mũi) và 8,3 log2ở vịt (tiêm 2 mũi)
trong khi đó gà có đáp ứng kháng thể HI với hiệu giá là 6,7 log2 và vịt là 8,7 log2khi được tiêm vacxin Re-5. Thử thách cường độc bằng virus cúm gia cầm A/H5N6 clade 2.3.4.4b cho thấy vacxin Navet-vifluvac bảo hộ được 80% đối với gà và 100% đối với vịt được tiêm phòng
còn vacxin Re-5 bảo hộ được 70% đối với gà và 100% đối với vịt đượctiêm phòng. Cả 2 loại vacxin đều có tác dụng làm giảm rõ rệt lượng virus bài thải từ gà, vịt đã tiêm phòng khi so sánh với động vật không được dùng vacxin

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