Đánh giá hiệu quả phòng bệnh của vacxin dịch tả heo Châu Phi nhược độc đông khô chủng G-DELTA- I177L trên heo

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Tác giả: Anh Thy Bùi, Huỳnh Thiên Thanh Đào, Thanh Thủy Đỗ, Nguyễn Hải Vy Hồ, Thị Ngọc Ánh Huỳnh, Thị Thu Phương Lê, Đức Huy Nguyễn, Quang Huy Nguyễn, Tấn Liêm Nguyễn, Văn Dung Nguyễn, Hào Quang Phạm, Thị Yến Như Phạm, Vô Ngôn Quách, Hữu Huy Trần, Xuân Hạnh Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học kỹ thuật Thú y, 2020

Mô tả vật lý: tr.5

Bộ sưu tập: Metadata

ID: 331146

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Mục tiêu của nghiên cứu này nhằm đánh giá hiệu quả phòng bệnh DTHCPcho heo khi tiêm vacxin DTHCPnhược độc đông khô chủng G-delta-I177L. Kết quả nghiên cứu cho thấy vacxin DTHCP nhược độc đông khôchủng G-delta-I177L do công ty NAVETCO nghiên cứu, sản xuất đạt các tiêu chuẩn về vô trùng, an toàn vàhiệu lực. Trong điều kiện phòng thí nghiệm, 100% heo tiêm vacxin của các lô khác nhau được bảo hộ chống lạivirus cường độc DTHCP phân lập tại Việt Nam. Vacxin cũng an toàn khi tiêm thử nghiệm cho heo trong điềukiện sản xuất và 80 - 100% heo tiêm vacxin được bảo hộ khi công cường độc. Heo đạt được trạng thái miễndịch bảo hộ sau 21 ngày tiêm vacxin, và không có sự khác nhau về khả năng đáp ứng kháng thể cũng như tỷlệ bảo hộ ở heo lai giống ngoại Yorkshire×Landrace và heo giống địa phương được tiêm cùng loại vacxin trên.The objective of this study was to evaluate the preventive efficacy against African swine fever virus (ASFV) of a lyophilized vaccine produced from the attenuated ASF virus G-delta-I177L strain on pigs. The studied results indicated that the G-delta-I177L strain-derived vaccine produced by NAVETCO met the requirements of sterility, safety and potency. Under the laboratory conditions, 100% of pigs vaccinated with different batches of the vaccine were protected from lethal doses of the virulent ASFV strain which was isolated in Viet Nam. The vaccine also showed safe for pigs in the field conditions and 80 - 100% of the vaccinated pigs were protected from challenging experiment with virulent strains on the 28th day post-vaccination. From the 21st day post vaccination, the pigs could obtain a solid immune status and there was no different in the antibody response and protection efficacy between the Yorkshire×Landrace hybrid pigs and the local pigs that was vaccinated with the same above ASF vaccine.

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