Along with the development of the industry in Vietnam, the beery industry has contributed greatly to the state budget and creating jobs for labours. However, beer wastewater contains high organic matter, some wastewater discharged parameters such as BOD, COD, Nitrogen, Phosphorus, etc. usually exceed the permitted standards. Based on the above practice, the research was conducted to evaluate the effectiveness of the horizontal flow wetland model, laboratory scale with organic loading rate varying from 20, 40, 60, 80, 100, 120 kg COD/ha.day. The results show that the concentration of pollutants in the effluent can reach QCVN 40: 2011/BTNMT, column A, before discharged into the environment.