The two-volume set LNCS 12415 and 12416 constitutes the refereed proceedings of of the 19th International Conference on Artificial Intelligence and Soft Computing, ICAISC 2020, held in Zakopane, Poland*, in October 2020. The 112 revised full papers presented were carefully reviewed and selected from 265 submissions. The papers included in the first volume are organized in the following six parts: neural networks and their applications
fuzzy systems and their applications
evolutionary algorithms and their applications
pattern classification
bioinformatics, biometrics and medical applications
artificial intelligence in modeling and simulation. The papers included in the second volume are organized in the following four parts: computer vision, image and speech analysis
data mining
various problems of artificial intelligence
agent systems, robotics and control. *The conference was held virtually due to the COVID-19 pandemic.