PHÂN LẬP TRITERPENOID SAPONIN TỪ LÁ CỦA LOÀI WEIGELA X “BRISTOL RUBY”

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Tác giả: Đức Hùng Nguyễn, Sỹ Danh Thường, Quang Tân Từ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2022

Mô tả vật lý: tr.100-108

Bộ sưu tập: Metadata

ID: 332156

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Chi Weigela, thuộc họ Kim ngân (Caprifoliaceae) gồm 10 loài có vùng phân bố chủ yếu tại châu Á. Tuy nhiên, có tới hơn 200 loài đã được lai tạo với các mục đích khác nhau như trang trí và thuốc chữa bệnh. W. x “Bristol ruby” là một loài cây bụi, có vùng phân bố chủ yếu tại châu Âu và được trồng với mục đích làm cảnh do có đặc tính dễ sinh trưởng và cho hoa màu sắc đẹp. Trước đó, phần rễ của loài thực vật này có chứa các hợp chất saponin triterpenoid dạng olean có một mạch đường, có hoạt tính gây độc mạnh trên dòng tế bào ung thư đại trực tràng (CT26). Dựa trên các phương pháp sắc ký, kết hợp với phương pháp phổ hiện đại một và hai chiều (1D và 2D NMR) và phổ khối lượng (ESI-MS), 2 hợp chất saponin triterpenoid dạng olean có hai mạch đường đã được tách chiết thành công từ cao chiết ethanol của lá của loài W. x “Bristol ruby”. Nghiên cứu đề xuất cần tiếp tục tiến hành đánh giá hoạt tính sinh học khác để có nhận định tổng quan về các hợp chất này.Weigela genus of Asparagaceae family contains 10 species which are distributed mainly in Asia region, however, there are more than 200 species which have been cultivated for many profits such as environmental beauty and medicinal use. Because of its beautiful flowering and facilating growth, W. x “Bristol ruby”, a shrub ornamental plant distributing commonly in Europe, are being planted for ornamental purpose. Previously, study on the roots of this species led to an identification of monodesmosidic oleanane-type triterpenoid saponins possessing a good cytotoxicity against a mouse colon cancer cell line (CT26). Based on chromatographical techniques, in combination with spectroscopic methods (1D and 2D NMR) and mass spectroscopy (ESI-MS in positive mode), two bidesmosidic oleanane-type triterpenoid saponins were isolated in success from the extract of the leaves of W. x “Bristol ruby”. A suggestion of further experiments was carried out on other evaluations of biological activity in order to achieve an overview on those compounds.

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