NGHIÊN CỨU PHÂN LẬP TRITERPENOID SAPONIN TỪ PHẦN LÁ CỦA LOÀI WEIGELA FLORIDA “PINK POPPET”

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Tác giả: Hoàng Mậu Chu, Đức Hùng Nguyễn, Quang Tân Từ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2022

Mô tả vật lý: tr.109-116

Bộ sưu tập: Metadata

ID: 332157

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The Weigela florida “Pink Poppet” is a shrub distributed widely in Europe and other regions in the world. This plant has been grown for comfort and ornamental purposes. It belongs to the genus Weigela, the family Caprifoliaceae known for the sources of saponins. Therefore, it is necessary to conduct a phytochemical study on the cultivar W. florida “Pink Poppet”. The research on the leaves of this plant resulted in the isolation and purification of three triterpenoid saponins, which have structural determinations as 3-O-a-L-arabinopyranosylhederagenin 28-O-b-D-xylopyranosyl-(1→6)-[a-L-rhamnopyranosyl-(1→2)]-b-D-glucopyranosyl ester (1), 3-O-a-L-arabinopyranosylhederagenin 28-O-b-D-glucopyranosyl-(1→6)-[a-L-rhamnopyranosyl-(1→2)]-b-D-glucopyranosyl ester (2), and 3-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosylhederagenin 28-O-α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→6)]-β-D-glucopyranosyl ester (3). Additionally, in this study, the relationship between the chemical structure and biological activities of the saponins was discussed, which is fundamental for evaluating the biological activities of these compounds in the future.W. florida “Pink Poppet” là một loài cây bụi, có vùng phân bố rộng ở châu Âu và trên thế giới và được trồng với mục đích làm cảnh. Loài thực vật này thuộc chi Weigela, họ Kim ngân (Caprifoliaceae) vốn được biết đến là nguồn cung cấp các hợp chất saponin có hoạt tính sinh học, do đó, việc nghiên cứu tách chiết thành phần saponin từ loài thực vật này là cấp thiết. Theo đó, nghiên cứu đã tách chiết được ba hợp chất triterpenoid saponin từ phần lá của loài W. florida “Pink Poppet”, có cấu trúc hóa học là 3-O-a-L-arabinopyranosylhederagenin 28-O-b-D-xylopyranosyl-(1→6)-[a-L-rhamnopyranosyl-(1→2)]-b-D-glucopyranosyl ester (1), 3-O-a-L-arabinopyranosylhederagenin 28-O-b-D-glucopyranosyl-(1→6)-[a-L-rhamnopyranosyl-(1→2)]-b-D-glucopyranosyl ester (2), và 3-O-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosylhederagenin 28-O-α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→6)]-β-D-glucopyranosyl ester (3). Tiếp đó, mối liên quan giữa cấu trúc hóa học và hoạt tính sinh học của các hợp chất saponin đã được bàn luận, là cơ sở để tiến hành đánh giá hoạt tính sinh học của các hợp chất saponin phân lập được trong các nghiên cứu tiếp theo.

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