THÀNH PHẦN HÓA HỌC VÀ HOẠT TÍNH SINH HỌC CỦA CAO CHIẾT TỪ THÂN CỦA LOÀI SUM LÔNG

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Hoàng Mậu Chu, Hữu Quân Nguyễn, Thị Thu Ngà Nguyễn, Thị Thúy Hằng Phó, Đại Dương Trần, Quang Tân Từ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2022

Mô tả vật lý: tr.232-239

Bộ sưu tập: Metadata

ID: 332174

Thêm vào giỏ Liên kết toàn văn

Adinandra glischroloma collected in Lao Cai province, Vietnam belongs to Adinandra genus. Some species of the Adinandra genus have been studied for their botanical characteristics and bioactive compounds, however, A. glischroloma has not been studied to date.Therefore, studying the chemical composition and biological activity of A. glischroloma stem extracts is necessary. The stem extracts of A. glischroloma have been quantified and determined whether they contain flavonoids, coumarins and polyphenolic compounds. The stem extracts were not able to inhibit the growth of the test bacteria (except, the dichloromethane extract inhibited B. subtilis and L. plantarum at a concentration of 200 µg/mL). The dichloromethane extract, ethyl acetate extract and ethanol extract have free radical reduction activity, which EC50 values reached 86.7, 88.5, and 111.2 µg/mL, respectively. The ethanol extract exhibited inhibitory activities on breast cancer, lung and gastric cell lines with IC50 values of 59.1, 63.23, and 67.48 µg/mL, respectively. The results show that A. glischroloma is a potential plant that contains many compounds that have biological activities that need to be further researched and exploited.Loài Sum lông có tên khoa học là Adinandra glischroloma Hand.-Mazz. var. hirta (Gagnep.) Kobuski, thuộc chi Dương đồng (Adinandra) phân bố ở tỉnh Lào Cai, Việt Nam. Một số loài thuộc chi Dương đồng đã được nghiên cứu về đặc điểm thực vật và các chất có hoạt tính sinh học, tuy nhiên loài Sum lông chưa được tác giả nào nghiên cứu. Do đó, phân tích thành phần hóa học và hoạt tính sinh học của cao chiết từ thân của loài Sum lông là nghiên cứu đầu tiên, mang tính thời sự và cần thiết. Cao chiết từ thân có chứa nhóm chất polyphenol, flavonoid và coumarin. Cao chiết từ thân không có khả năng ức chế vi khuẩn kiểm định (ngoại trừ cao dichloromethane ức chế B. subtilis và L. plantarum ở nồng độ 200 µg/mL). Cao dichloromethane có hoạt tính chống oxi hóa mạnh nhất, tiếp đến là ethyl acetate và thấp nhất là ethanol với giá trị EC50 lần lượt là 86,7
88,5 và 111,2 µg/mL. Cao ethanol có hoạt tính ức chế các dòng tế bào ung thư vú, phổi và dạ dày với giá trị IC50 lần lượt là 59,1
63,23 và 67,48 µg/mL. Kết quả này cho thấy, loài Sum lông là cây trồng tiềm năng chứa nhiều hợp chất có hoạt tính sinh học cần được tiếp tục nghiên cứu và khai thác.

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR