HOẠT TÍNH CHỐNG OXY HÓA VÀ GÂY ĐỘC TẾ BÀO CỦA LOÀI CỎ MÁU (MILLETTIA DIELSIANA) Ở VIỆT NAM

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Tác giả: Thị Ngọc Hà Đặng, Việt Hùng Đào, Thanh Huế Phạm, Thị Thùy Dương Trần, Thị Thu Lê Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2022

Mô tả vật lý: tr.558-564

Bộ sưu tập: Báo, Tạp chí

ID: 332398

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Cây Cỏ máu là một cách gọi dân gian của người xưa, khi dịch của cây tiết ra gần giống với máu người, có tên khoa học Millettia dielsiana, thuộc họ Đậu (Fabaceae) có vị đắng, tính bình. Theo kinh nghiệm dân gian, cây có công dụng làm thuốc chữa thiếu máu, lưng gối đau mỏi, chân tay tê liệt, viêm khớp, an thần gây ngủ, tăng cường bài tiết và kinh nguyệt không đều,… Cặn tổng (MD) và cặn etyl axetat (MDE) thể hiện hoạt tính chống oxi hóa theo phương pháp DPPH tốt nhất với giá trị SC (%) lần lượt là 75,15 ± 0,3 và 79,01 ± 0,8%, tương ứng với giá trị SC50 bằng 27,06 và 25,68 µg/mL. Cặn n-hexan (MDH) và nước (MDW) hầu như không thể hiện hoạt tính. Các cặn MD, MDH, MDE và MDW thể hiện hoạt tính gây độc đối với các tế bào ung thư gan (Hep-G2), cổ tử cung (HeLa) và vú (MCF-7) theo phương pháp MTT ở các mức độ khác nhau. Trong đó, cặn MDE biểu hiện hoạt tính gây độc với tế bào ung thư Hep-G2 và MCF-7 tốt với giá trị IC50 lần lượt là 18,45 µg/mL và 13,52µg/mL. Cặn MD biểu hiện khả năng ức chế tế bào ung thư Hep-G2 tốt nhất với giá trị IC50 lần lượt là 15,01 µg/mL. Bên cạnh đó, các cặn chiết không thể hiện hoạt tính với dòng tế bào thường Vero.Co mau (Millettia dielsiana) is a traditional Vietnamese medicinal plant and belongs to the Fabaceae family with a bitter taste. According to folk experience, this plant is used to treat back pain, knee pain, anemia, paralysis of the limbs, sedation, arthritis, enhanced secretion clearance, and menstrual irregularity. Ethanol extract (MD) and ethyl acetate fraction (MDE) exhibited the highest antioxidant activity using the DPPH method with SC (%) values of 75.15 ± 0.3 and 79.01 ± 0.8%, respectively, and SC50 values calculated of 27.06 and 25.68 µg/mL, respectively. The remaining fractions (MDH, MDW) of MD extract showed no activity. The MD extract and its fractions exhibited cytotoxic activity against human hepatoma cell line (Hep-G2), cervical cancer cells (HeLa), and breast adenocarcinoma cells (MCF-7) according to the MTT method. MDE fraction showed good cytotoxic activity against Hep-G2 and MCF-7 cells with IC50 values of 18.45 µg/mL and 13.52 µg/mL, respectively. The MD extract has the best ability to inhibit the Hep-G2 cancer cell line with IC50 values of 15.01 µg/mL. In addition, the MD extract and its fractions did not exhibit inhibitory activity against Vero cells.

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