This book gathers a selection of peer-reviewed papers presented at the second Big Data Analytics for Cyber-Physical System in Smart City (BDCPS 2020) conference, held in Shanghai, China, on 28–29 December 2020. The contributions, prepared by an international team of scientists and engineers, cover the latest advances made in the field of machine learning, and big data analytics methods and approaches for the data-driven co-design of communication, computing, and control for smart cities. Given its scope, it offers a valuable resource for all researchers and professionals interested in big data, smart cities, and cyber-physical systems.