Human resource had inevitably been a key factor in contributing to South Korea’s high technology boom and rapid economic growth. Sharing similarities in historical situation, social and economic condition, lessons from what South Korean government had implemented to develop skilled manpower that meets economic development needs would be valuable for Vietnam situation in general and Ho Chi Minh City in particular. Firstly, this study clarified the reciprocal relation of education, human resource and economic development. Then, it focused on analyzing and finding out effective policies in human resource development of Ho Chi Minh City from South Korea’s case study.