ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ KẾT QUẢ ĐIỀU TRỊ HỘI CHỨNG THẬN HƯ KHÁNG CORTICOSTEROID Ở TRẺ EM TẠI BỆNH VIỆN SẢN NHI BẮC NINH

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Minh Hiệp Nguyễn, Thị Hiếu Nguyễn, Thị Xuân Hương Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2023

Mô tả vật lý: tr.57-63

Bộ sưu tập: Metadata

ID: 333168

Thêm vào giỏ Liên kết toàn văn

Nghiên cứu mô tả đặc điểm lâm sàng, cận lâm sàng và phân tích kết quả điều trị trẻ mắc hội chứng thận hư tiên phát kháng Corticosteroid. Nhóm tác giả thực hiện mô tả tiến cứu trên 37 trẻ mắc hội chứng thận hư tiên phát kháng Corticosteroid ở trẻ em tại Bệnh viện Sản Nhi Bắc Ninh từ tháng 01/2021- 12/2021. Kết quả nghiên cứu có 27/37 (73%) nam, 10/37 (27%) nữ, tỷ lệ nam/nữ: 2,7/1, tuổi trung bình 10,1±3,3 tuổi. Lâm sàng: 54,1% (20/37) hội chứng thận hư thể đơn thuần, 94,6% (35/37) hội chứng thận hư tiên phát, 100% có phù ở các mức độ, trong đó 27,1% (10/37) phù nặng, 6/37 (16,2%) tăng huyết áp. Cận lâm sàng: 28/37 (75,7%) tăng số lượng bạch cầu, 100% giảm albumin máu, 36/37 (97,3%) giảm protein máu, 02/37 (5,4%) thiếu máu và tăng ure máu, 01/37 (2,7%) tăng creatinin mức độ nhẹ. Kết quả điều trị mức độ phù giảm dần qua thời gian điều trị, sau 6 tháng, 12 tháng tỷ lệ không phù đã tăng nhanh (đều trên 90%). Thời gian trung bình protein niệu trở về âm tính là 1,76 ± 0,99 tháng. Có sự giảm dần số lượng bạch cầu trở về giới hạn bình thường qua thời gian điều trị và có sự giảm lượng urea máu có ý nghĩa thời điểm sau 12 tháng điều trị so với sau 6 tháng (p<
0,05), tỷ lệ kết quả điều trị chung 21/37 (56,8%) tốt. Biểu hiện lâm sàng, cận lâm sàng của bệnh nhi mắc hội chứng thận hư kháng Corticosteroid nặng nề, kết quả điều trị chung chưa cao.This study describes the clinical, paraclinical features and outcomes in children with corticosteroid-resistant nephrotic syndrome at Bac Ninh Children's Hospital. Description prospective was studied on 37 children with Corticosteroid-resistant nephrotic syndrome, hospitalized in the Bac Ninh Children's Hospital from 1/2021 to 12/2021. The results revealed that, in 37 examined children, there were 27/37 (73%) male, and 10/37 (27%) female, rate of male/female were 2.7/1. The median age was 10.1±3.3 years old. The clinical condition was characterized by 54.1% (20/37) of Simple nephrotic syndrome, and 94.6% (35/37) of Primary nephrotic syndrome. Patients often had 100% with edema of various degrees of which 27.1% (10/37) had severe edema, and 6/37 (16.2%) had hypertension. Paraclinical features were 28/37 (75.7%) increased white blood cell count, 100% hypoalbuminemia, 36/37 (97.3%) decreased plasma proteins, 02/37 (5.4%) anemia and increased blood urea, Creatinine concentrations increased was 01/37 (2.7%). As a result of treatment, the degree of edema decreased gradually over time of treatment, after 6 months, and 12 months (all over 90%). The mean time for proteinuria to return negative was 1.76 ± 0.99 months. There was a gradual decrease in the number of leukocytes back to the normal limit over the course of treatment and there was a significant decrease in blood urea after 12 months of treatment compared to after 6 months (p<
0.05), the ratio Overall treatment outcome rate is 21/37 (56.8%) good. Characteristic clinical and subclinical manifestations of pediatric patients with severe corticosteroid-resistant nephrotic syndrome, the proportion of complete remissions was degree median.

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR