ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG BỆNH NHI THALASSEMIA TẠI BỆNH VIỆN ĐA KHOA TỈNH CAO BẰNG NĂM 2021

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Tác giả: Thị Huệ Đoàn, Thị Phương Dung Hoàng, Trung Kiên Phạm

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2023

Mô tả vật lý: tr.64-69

Bộ sưu tập: Metadata

ID: 333169

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In this study, we analyzed the clinical and hematological characteristics of children diagnosed with thalassemia at Cao Bang General Hospital 2021. A crosssectional study were performed on 93 patients with thalassemia treated at the Cao Bang General Hospital from 6/2021 to 6/2022 by face-to-face interview and medical examination of patients. 43% of age groups with a diagnosis of thalassemia were 6-10 years old, and the average age on admission was 7.17±3.48 years old. 60.2% were Tay's ethnic, and 97.5% were diagnosed with β-thalassemia. Common clinical features were enlarged spleen (88.2%), pale mucous membranes (78.5%), paleness of the skin palm (77.4%), stunting malnutrition (51.6%), jaundice and the whites of the eyes (50.5%). Subclinical characteristics were 68.8% hypochromia red blood cells <
60g/l, 95.7% Hematocrit decreased <
25%, 64.5% indirect hyperbilirubinemia, 63.4% Elevated serum iron >
27 µmol/l, 69.9% Elevated serum ferritin >
1000 ng/m, 55.2% skull x-ray abnormalities. The most common genotype was β-thalassemia. Common clinical features were splenomegaly, pale mucous membranes, pale palms, stunting malnutrition. Common subclinical features were moderate anemia, indirect hyperbilirubinemia, Elevated serum iron and ferritin.Nghiên cứu mô tả đặc điểm lâm sàng, cận lâm sàng bệnh nhi Thalasemia tại Bệnh viện Đa khoa tỉnh Cao Bằng năm 2021. Nghiên cứu mô tả cắt ngang trên 93 bệnh nhi được chẩn đoán xác định Thalassemia vào điều trị tại Bệnh viện Đa khoa tỉnh Cao Bằng từ tháng 6/2021 đến tháng 6/2022 qua phỏng vấn trực tiếp thân nhân bệnh nhi bằng bộ câu hỏi được thiết kế sẵn và kết hợp thăm khám bệnh nhân. Nhóm tuổi phát hiện bệnh khi vào viện nhiều nhất là 6-10 tuổi (43%), tuổi trung bình 7,17± 3,48 tuổi, 60,2% dân tộc Tày, 14,3% có anh chị em mắc bệnh thalassemia, 6,5% người thân mắc bệnh thalassemia, 3,2% trường hợp hôn nhân cận huyết, 95,7% thể β-Thalassemia. Đặc điểm lâm sàng hay gặp: lách to (88,2%), da niêm mạc nhợt (78,5%), lòng bàn tay nhợt (77,4%), suy dinh dưỡng thể thấp còi (51,6%), vàng da/mắt vàng (50,5%). Đặc điểm cận lâm sàng: 68,8% Hemoglobin giảm <
60g/l
95,7% Hematocrit giảm <
25%
64,5% Bilirubin gián tiếp tăng >
24 µmol/l
63,4% sắt huyết thanh tăng >
27µmol/l
69,9% Ferritine tăng >
1000 ng/ml, 55,2% Xquang xương sọ bất thường. Thể thường gặp nhất là β-Thalassemia. Triệu chứng điển hình: lách to, da niêm mạc nhợt, lòng bàn tay nhợt, suy dinh dưỡng thể thấp còi. Xét nghiệm có thiếu máu mức độ trung bình, tăng Bilirubin gián tiếp, sắt huyết thanh và ferritin huyết thanh tăng nhiều.

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