MỘT SỐ YẾU TỐ LIÊN QUAN ĐẾN KẾT QUẢ XÉT NGHIỆM ĐÔNG CẦM MÁU CỦA BỆNH NHÂN THALASSEMIA TẠI BỆNH VIỆN TRUNG ƯƠNG THÁI NGUYÊN

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Tác giả: Thị Thanh Mai Đặng, Thị Kim Tiến Nguyễn, Chí Doanh Phùng, Thế Hoàng Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2023

Mô tả vật lý:

Bộ sưu tập: Metadata

ID: 334311

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A cross-sectional descriptive study was conducted at Thai Nguyen National Hospital in 2021 on 96 thalassemia patients. This study aim to determined the associaton between some disease characteristics and blood coagulation test results of thalassemia patients. The study results showed the average platelets was 408,31 ± 244,50 (103/ml)
average prothrombin time 15.15 ± 1.55 (seconds)
average activated partial thromboplastin time 38.70 ± 6.86 (seconds) and fibrinogen was 2.70 ± 0.73 (g/l). There were associations between thrombosis, direct Coombs test (+) and spleen status with platelet (p<
0.05). There were associatons between spleen and liver status and prothrombin time (p<
0.05). There were associatons between direct Coombs test (+), spleen status and liver status with prothrombin time ratio (%) (p<
0.05). There were associations between liver status and activated partial thromboplastin time, activated partial thromboplastin time ratio (p<
0.05) and fibrinogen (p<
0.05). The study has found associations between spleen and liver status of thalassemia patients and blood coagulation test results.Nghiên cứu mô tả cắt ngang trên 96 bệnh nhân thalassemia tại Bệnh viện Trung ương Thái Nguyên năm 2021. Nghiên cứu này nhằm mục tiêu xác định mối liên quan giữa một số đặc điểm bệnh với kết quả xét nghiệm đông cầm máu của bệnh nhân thalassemia. Kết quả nghiên cứu cho thấy số lượng tiểu cầu trung bình là 408,31 ± 244,50 (103/ml)
thời gian prothrombin trung bình là 15,15 ± 1,55 (giây)
thời gian hoạt hóa thromboplastin trung bình là 38,70 ± 6,86 (giây) và nồng độ fibrinogen là 2,70 ± 0,73 (g/l). Kết quả nghiên cứu thấy có mối liên quan giữa tình trạng có huyết khối, nghiệm pháp Coombs trực tiếp (+) và tình trạng lách với số lượng tiểu cầu (p<
0,05). Tình trạng lách, gan của bệnh nhân có liên quan với thời gian prothrombin (p<
0,05). Nghiệm pháp Coombs trực tiếp (+), tình trạng lách và tình trạng gan của bệnh nhân có liên quan với tỉ lệ phần trăm phức hệ prothrombin (p<
0,05). Tình trạng gan của bệnh nhân có liên quan với thời gian hoạt hóa thromboplastin (giây), tỉ số thời gian hoạt hóa thromboplastin (bệnh/chứng) (p<
0,05) và fibrinogen (p<
0,05). Nghiên cứu cho thấy có mối liên quan giữa tình trạng lách và gan của bệnh nhân thalassemia với kết quả xét nghiệm đông cầm máu.

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