The Oc Eo culture is a major scientific topic that has been attracting the research interest of domestic and foreign scholars. However, to this day, the origin of the Oc Eo culture has not yet been thoroughly clarified. In general, researchers agree that the Oc Eo culture was formed by a combination of endogenous and exogenous factors, with many different routes, and, up until now, there has not been any comprehensive work on the transition of this culture to southern Vietnam. Based on archaeological sources discovered in the Can Gio-Long Son area, especially at Giong Lon site, the author provides some comments on the formation process of Oc Eo culture in the southeastern coastal region.