XÂY DỰNG PHƯƠNG PHÁP PHÂN TÍCH ĐỒNG THỜI KETAMIN VÀ MỘT SỐ CHẤT ĐỘN TRONG NƯỚC THẢI BẰNG SẮC KÝ LỎNG KHỐI PHỔ (LC-MS/MS)

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Tác giả: Thị Ngọc Lan Đặng, Thị Quỳnh Như Nguyễn, Thị Thuỳ Linh Nguyễn, Xuân Trường Nguyễn, Thị Thanh Hà Phạm, Nguyên Hà Trần, Mạnh Cường Trương, Ngân Bình Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2022

Mô tả vật lý: tr.180 - 188

Bộ sưu tập: Metadata

ID: 335597

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In manufacturing nacortics, apart from the non-bioactive agents used as diluents just to increase the mass, some pharmaceutical compounds are also used as diluent agents to combine the bioactivity. These diluents are normally added during the final manufacturing or packaging step. Therefore, the determination of these diluents in wastewater may contribute to the investigation of illegal nacortic production site. In this study, an ultraperformance liquid chromatography tandem mass spectrometric method was used for the simultaneous analysis of ketamine and 6 diluent agents (nicotiamide, trimethoprim, chlorpheniramin, cafein, paracetamol and dextropropoxyphen) in wastewater, using liquid-liquid extraction for sample treatment. The chromatographic method was developed using C18 column with acetonitrile and water containing 0.1% acid formic as mobile phase, and detected by (ESI+) with MRM signal. Validation results proved the feasibility of the method for application. The correlation coefficients of the calibration curves were 0.9981 – 0.9995 for the quantitation range of 0.05 ppb to 10.0 ppb. The repeatability result is good with RSD% (2.9% - 11.0%) at different concentrations.Trong sản xuất các chất ma tuý, một số chất độn không hoặc có hoạt tính sinh học được thêm vào nhằm tăng khối lượng thu lợi nhuận hoặc tăng tác động kích thích của chất ma túy thường được đưa vào tại các bước tổng hợp, đóng gói. Do đó, việc phát hiện sự có mặt của một số chất độn cùng với ma tuý trong nước thải ở khu vực nghi ngờ có cơ sở sản xuất trái phép sẽ cung cấp thêm thông tin hữu ích cho cơ quan điều tra. Trong nghiên cứu này, phương pháp LC-MS/MS được xây dựng để định lượng đồng thời ketamin và 6 chất độn (nicotinamid, trimethoprim, clopheniramin, cafein, paracetamol và dextropropoxyphen) trong nước thải, xử lý mẫu bằng chiết lỏng -lỏng. Phương pháp phân tích này đã đưa ra một chương trình sắc ký sử dụng cột C18 với acetonitril và nước chứa 0,1% acid formic, và phát hiện bằng (ESI+) với tín hiệu MRM. Kết quả thẩm định phương pháp cho thấy tính khả thi trong ứng dụng. Các đường chuẩn cho hệ số tương quan tốt 0,9981 - 0,9995 trong khoảng khảo sát từ 0,05 ppb đến 10,0 ppb, cho kết quả tương đối lặp lại với RSD% dao động từ 2,9% - 11,0% ở các ngưỡng nồng độ khác nhau.

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