Khảo sát hoạt tính sinh học của ba saponin phân lập từ quả cà dại hoa trắng Solanum torvum Sw

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Tác giả: Bích Ngọc Giàu Lư, Vũ Thụy Vy Nguyễn, Thiện Vy Phan

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Nguyễn Tất Thành, 2022

Mô tả vật lý: tr.14

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ID: 335801

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Three saponosides (steroidal glycosides), neochlorogenin 6-O-α-L-rhamnopyranosyl-(1→3)-β-D-quinovopyranoside (S-1), (25S)-6α-hydroxy-5α-spirostan-3-on-6-O-α-L-rhamnopyranosyl-(1→3)-β-D-quinovopyranoside (S-2) and solanolactoside A (S-3), previously isolated form the ethyl acetate fraction of Solanum torvum Sw. fruits were evaluated for cytotoxic activities against four cancer cells lines. In our study, S-1 showed moderate inhibitory activities against HepG2, K562 and MCF-7 cancer cell lines with IC50 values of (41.38 ± 2.53) mM
(23.04 ± 2.52) mM, and (12.04 ± 2.28) mM, respectively. S-2 exhibited strong cytotoxic effects on K562 and MCF-7 cancer cell lines with IC50 values of (12.04 ± 2.69) mM and (12.04 ± 2.99) mM, respectively. Meanwhile, the cytotoxic activities of S-3 against all tested cancer cell lines were not observed. The result of the study is consistent with previous studies on S. torvum and provides more information to improve its application possibility for cancer treatment.Từ nghiên cứu trước đó, tác giả đã phân lập được ba saponin, neochlorogenin 6-O-α-L-rhamnopyranosyl-(1→3)-β-D-quinovopyranosid (S-1), (25S)-6α-hydroxy-5α-spirostan-3-on-6-O-α-L-rhamnopyranosyl-(1→3)-β-D-quinovopyranosid (S-2) và solanolactosid A (S-3) từ phân đoạn cao ethyl acetat (EtOAc) của quả cà dại hoa trắng Solanum torvum Sw. Dựa trên một số nghiên cứu về tiềm năng của các glycosid steroid trong quả Solanum torvum Sw. có 3 saponin được thử hoạt tính độc tế bào. Kết quả cho thấy S-1 và S-2 có hoạt tính độc tế bào đáng được quan tâm. S-1 có khả năng ức chế mạnh 3 dòng tế bào ung thư HepG2, K562 và MCF-7 với giá trị IC50 tương ứng là (41,38 ± 2,53) mM, (23,04 ± 2,52) mM và (12,04 ± 2,28) mM. S-2 có khả năng gây độc mạnh trên 2 dòng tế bào ung thư K562 và MCF-7 với IC50 lần lượt là (12,04 ± 2,69) mM và (12,04 ± 2,99) mM. S-3 không có hoạt tính gây độc tế bào. Kết quả thử nghiệm phù hợp với các nghiên cứu trước đó và cung cấp thêm thông tin làm tăng khả năng ứng dụng của quả cà dại hoa trắng trong hỗ trợ điều trị bệnh ung thư.

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