Khảo sát các đặc tính của màng hydrogel poly (vinyl alcohol) glutaric anhydride tải nano bạc

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Tác giả: Hoàng Long Ngô, Ngân Tuấn Nguyễn, Ngọc Phương Trâm Nguyễn, Quang Hiếu Vũ

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Nguyễn Tất Thành, 2022

Mô tả vật lý: tr.1

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ID: 335837

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Hydrogel poly (vinyl alcohol) is a network of Polyvinyl alcohol (PVA) polymers which has various application in biomedicine, especially in wound healing. In wound treatment, the hydrogel should have strong stability as well as anti-bacteria effect in order to protect the opened wound from physical and biological interaction. For these purposes, the study on the characterization of silver nanoparticle loaded hydrogel Poly (vinyl alcohol) Glutaric anhydride has been done. The polymer also had its stability reinforced through the cross-linking between the poly (vinyl alcohol) and the solidifier glutaric anhydride structures. The results on Fourier transformed infrared spectrum have shown the bonding between PVA polymer via (−OCO) at the wave length 1,700 cm-1. The PVA-GA hydrogel has lower degradation rate than the control (17 % vs 25 %). In biological test, the PVA –GA Ag nanoparticles have proved the ability to eradicate the P. aeruginosa after 2 hours and S. aureus after 4 hours after directed contact. These results in vitro have proved the statbility and antibacterial effect of PVA-GA- Nano Ag. Even though more tests should be performed, the hydrogel has showed great potential in wound healing.Hydrogel poly là màng được hình thành dựa trên liên kết giữa các mạch polymer poly (vinyl alcohol). Màng hydrogel có nhiều ứng dụng trong lĩnh vực y sinh học nhất là mảng che phủ vết thương. Để làm được điều này, màng cần có các tính chất như độ bền cao và có khả năng kháng khuẩn nhằm bảo vệ vết thương khỏi tác động vật lí và sinh học. Trong nghiên cứu này, đối tượng được hướng đến là màng hydrogel poly có thành phần nano bạc, ngoài ra, màng poly được tăng cường độ bền thông qua việc tạo liên kết nối mạch giữa mạch poly và chất đóng rắn glutaric anhydride. Kết quả phổ hồng ngoại Fourier chứng minh màng poly có độ bền cao do có các liên kết (−OCO) giữa các mạch polymer poly ở bước sóng 1 700 cm-1. Màng poly-glutaric anhydride có độ phân rã thấp hơn so với màng poly đối chứng (17 % so với 25 %). Trong thử nghiệm sinh học, màng poly-glutaric anhydride tải hạt nano bạc được chứng minh có tính kháng P. aeruginosa trong 2 giờ và S. aureus trong 4 giờ khi tiếp xúc. Kết quả sơ bộ trong phòng thí nghiệm trên đã chứng minh được độ bền và hoạt tính sinh học của màng hydrogel poly-glutaric anhydride tải hạt nano bạc.

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