Leaves of Phyllanthus acidus were collected in Binh Thuan province and extracted with methanol at room temperature to obtain a methanol extract. Carry out complete dispersion of methanol residue into the water and extracts with increased polarization solvents: n-hexane, chloroform, ethyl acetate, and n-butanol solvents, respectively, to obtain the respective residue fractions. The ethyl acetate extraction was performed with column chromatography several times and isolated eight pure compounds to be 1, 2, 3, 4, 5, 6, 7, and 8. Their chemical structures were determined based on analysis of 1D, 2D-NMR nuclear magnetic resonance spectroscopy data, combined with reference comparison. This is the first time eight compounds have been reported on the isolation and determination of their structure from ethyl acetate extraction from the leaves of Phyllanthus acidus collected in Binh Thuan province.