This study involves the issues of the university major and profession choice of high school students based on factors that influence students’ choice. The results show that the current trend of students choosing the major and profession is typically embedded in “hot” majors and occupations with a high income. The findings also indicated 11 factors influencing significantly on students’ choices. Of 11 factors, “Advice of family members” and “Job opportunities in the future” factors had a strong influence on students’ choices. These findings provide teachers and professional consultants with a better understanding of factors affecting students’ choices of university majors and occupations t Based on the study findings, some suggestions have been recommended to teachers, profession consultants and parents, and those directly involved in choosing the university major and profession of students.