This article studies the influence of the construction sequence on the response of reinforced concrete high-rise buildings. Currently, most structural systems are analyzed in only a single step with the assumption that the system can bear the entire load from the completed whole building. In reality, a structure is constructed sequentially floor by floor, which leads to differences between the theoretical analysis and the actual response of structural system, especially for the structural system of high-rise buildings. After conducting construction sequence analysis, the effecting results on the internal forces of columns and beams of the changeable high skycraper are synthesized, compared with using the conventional technique.