The study aimed to find out the impact of Interactive Online Teaching and Learning (IOTL) on students’ performance. For that purpose, the researcher selected the sample of a total of about 6,300 non-English major freshmen and 94 teachers of English teaching those students at Hanoi University of Business and Technology (HUBT) to experiment with the teaching and learning activities via an online software called ZOOM in a 6-week period, from 16 March to 28 April 2020, the time for “social distance” because of the Covid 19 Pandemic. The quantitative and qualitative approaches were applied to collect the data. Statistical techniques and synthesis of narrative data were used to analyze the data gathered from a semi-structured questionnaire, online teacher interviews, achievement test results and the researcher’s class observation. The findings of the study revealed that IOTL can prove to be an efficient and convenient methodology in terms of: 1. enhancing students’ performance
2. promoting student motivation and inspiration in learning
3. strengthening students’ learning engagement 4. improving the students’ achievement test results
4. indicating the students’ English learning preference
5. quickly adapting to the modern learning mode
6. bettering the relationship between students and teachers. However, the findings also indicated two main shortcomings of IOTL: the lack of face-to-face meetings and social interactions, and LearningManagement System (LMS). In the light of the findings, it is recommended that blended learningwhich combines online and on-campus should be implemented in the coming time because ofits great benefits, the software must be an LMS, and facilities for teaching and learning onlineshould be well equipped to fulfil the education tasks