This research examines the impact of tourism and local residents support for development of tourism destination in the Cu Chi, Hochiminh City. The study conducts a survey by using a formal questionnaire with participation of 291 residents who are living in Cu Chi, five research hypotheses were proposed. The findings show that the economic impacts of tourism were most favorably behavioral control and socio-cultural factor. Tourism service generates great pressure on local resources, impact on energy consumption, food, and other raw materials requirements that are in shortage and unavailability. Besides that, tourism causes pollution and exhausts environment as any other industries. For long-term strategy of tourist development, tourism must incorporate the principles and practices of sustainable consumption.