Currently, the occurrence of antibiotic in the water environment has raised serious concerns. Therefore, the effective removal of antibiotic pollutants has become a research hotspot in the field of water treatment. This study reported the results of removal of the antibiotic Ciprofloxacin (CFX) in water using ZnOBiochar materials (RHZ) fabricated by sonochemical method. ZnO-Biochar materials was characterized by X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM) . The influence of factors such as pH (3-9), a mass of RHZ material (200-500 mg), and the initial concentration of CFX (10-100 ppm) was investigated. The research results show that, at the optimal conditions for CFX processing: pH=5.0, RHZ dosage is 4g/L, CFX concentration is 10 ppm, about 96.59% of CFX has been processed in the CFX process. time 180 minutes.