In this study, Zinc Oxide Nanostructures (UZ) were synthesized by the sonochemical method and tested in seed treatment of maize seeds. The experiment was arranged in a completely randomized block design with 3 replications. Corn seed was soaked in UZ solution with different concentrations (0.8 ÷ 3.2 mg/kg grain) for different times (10, 90, 180, 270 min) and one control formula in which no UZ was used. The results showed that the dose of 3.2mg UZ/kg of corn kernels soaked for 90 minutes gave the best results, with the highest growth, germination rate, and seedling quality, drought tolerance index, relative increase of 39.10% compared to the control formula. The result of this study is the scientific basis to propose solutions to improve drought tolerance, growth, and development of some plant varieties in Vietnam through the use of UZ.