Avocado is one of the key fruit trees of the Central Highlands and especially Dak Nong province. The current important issue of agricultural production is the output of products. In order to increase crop productivity, modern tools are needed to apply, one of which is foliar fertilizer. Micro-nutrient nano foliar fertilizer has been studied and used on many subjects, however, in Vietnam, the use of this hightech product in avocado cultivation is not available. The research framework presents the effectiveness of using micro-nano foliar fertilizer on avocado varieties 034 and Booth 7 with good effects to increase fruit set rate, increase yield by 11% compared to the control without using. Besides, it does not affect post-harvest fruit quality and soil quality