Oxindole (indol-2-one) is a crucial scaffold in medicinal chemistry for very common commercial drugs. In our work, two oxindole derivatives have been synthesized, and confirmed by 1H & 13C-NMR, IR andMS data. Compound 2 and 3 showed potent inhibitory activity against α-glucosidase with IC50 values of 57.5 and 348.7 μM, respectively. Molecular docking has been studied for the binding interactions of these compounds with the active sites of the enzyme. Moreover, parameters drug-likeness and ADME properties were calculated