CÁC ĐỘT BIẾN TRÊN PROTEIN GAI CỦA CÁC DÒNG PHỤ OMICRON

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Tác giả: Thế Quang Trương

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học - Đại học Văn Lang, 2022

Mô tả vật lý: tr.70

Bộ sưu tập: Metadata

ID: 338182

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Nhận diện được trên protein gai của dòng phụ BA.1 có 34 đột biến, dòng phụ BA.2 có 32 đột biến và dòng phụ BA.3 có 25 đột biến. Số đột biến trên RBD của dòng phụ BA.1, BA.3 là 15 và BA.2 là 16. Trên RBD dòng phụ BA.1 có ba đột biến đặc trưng là S371L, G446S và G496S, dòng phụ BA.2 có bốn đột biến đặc trưng là S371F, T376A, D405N và R408S, dòng phụ BA.3 có ba đột biến đặc trưng là S371F, D405N và G446S. Trên protein gai của dòng phụ BA.2 có mười đột biến duy nhất là T19I, L24S, P25del, P26del, A27S, V213G, T376A và R408S làm dòng phụ này có khả năng lây nhiễm gấp khoảng 20 lần so với biến thể Gốc ban đầu, 4,2 lần so với biến thể Delta và khoảng 1,5 lần so với dòng phụ BA.1. Các đột biến trên vùng RBD protein gai của các dòng phụ BA.1, BA.2 và BA.3 là K417N, E484A và Q493R đều gây rối loạn cho nhiều kháng thể. Trên vùng RBD, đột biến đặc trưng G496S của dòng phụ BA.1 và các đột biến đặc trưng T376A, D405N, R408S của dòng phụ BA.2 làm giảm hiệu quả của nhiều kháng thểWe identified on the spike protein of the BA.1 sublineage with 34 mutations, the BA.2 sublineage with 32 mutations and BA.3 sublineage with 25 mutations based on the results of the pairwise S sequences alignment problem of each Omicron variant and the reference S sequence. The number of mutations on RBD of the BA.1, BA.3 sublineage is 15 and the BA.2 sublineage is 16. On the RBD, the BA.1 sublineage has three characteristic mutations, namely S371L, G446S and G496S, the BA.2 sublineage has four characteristic mutations, namely S371F, T376A, D405N and R408S, the BA.3 sublineage has three characteristic mutations are S371F, D405N and G446S. On the spike protein of the BA.2 sublineage, there are ten unique mutations, namely T19I, L24S, P25del, P26del, A27S, V213G, T376A and R408S, making this sublineage about 20 times more infectious than the Original variant, 4.2 times that of the Delta variant and about 1.5 times that of the BA.1 sublineage. Mutations on the RBD spike protein region of the BA.1, BA.2 and BA.3 sublineages K417N, E484A and Q493R all cause disorder for many antibodies. On the RBD region, the specific mutation G496S of the BA.1 sublineage and the specific mutations T376A, D405N, R408S of the BA.2 sublineage reduced the effectiveness of many antibodies

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