Objective: To describe changes in knowledge of recurrence prevention among hemorrhage peptic ulcer patients. Methods: A single-arm experimental study design was conducted on a group of 72 patients diagnosed with hemorrhage peptic ulcer and treated at Nghe An General Hospital, from February 2022 to May 2022. Results: Mean of basic knowledge about the disease increased significantly from 2.19 ± 1.06 before intervention to 5.14 ± 0.95 after intervention (p <
0,01)
knowledge of recurrence prevention was changed significantly with p<
0,01 as follows: diet from 4.74 ± 1.91 to 9.15 ± 1.27
lifestyle from 4.60 ± 1.33 to 6.83 ± 1.07
drugs use from 2.06 ± 1.40 to 6.10 ± 1.09. Conclusion: The results showed that health education significantly changes knowledge of recurrence prevention in patients with hemorrhage peptic ulcers. These results confirm the important role of health education and this activity should be maintained in patient care.