Objectives: To describe current status of knowledge and practice of myocaridal infarction (MI) prevention and toevaluate effectiveness of health education intervention on MI prevention among - patients with type 2 diabetes and dyslipidemia treated at the Vietnam National Hospital of Endocrinology in 2022. Participants and methods: An interventional study was conducted on 62 inpatients with type 2 diabetes and dyslipidemia treated at the Department of Cardiology and Metabolic Disorders of Vietnam National Hospital of Endocrinology from June to August 2022. The intervention was guided by the MOH guidelines with the sessions on knowledge and practice of myocardial infarction and infarction prevention. The knowledge and practice questionnaire were used to measure outcomes at three-point times, namely, baseline, post-intervention, and follow-up. Results: The average score of knowledge about myocardial infarction prevention of the participants was 35.61 ± 9.33 out of 57 points. In which, 17.74% had poor knowledge. The participants with poor practice accounted for 6.45%. There was a change in the mean score of knowledge and practice about myocardial infarction prevention after health education intervention with p <
0,001, however, the results rarely remained overtime with p >
0,05. Conclusion: Health education intervention was demonstrated to improve the participants’ knowledge and practice of MI prevention. In nursing care practice, health education related to knowledge and practice of MI prevention for patients with type 2 diabetes and dyslipidemia should be maintained and strengthened.