Nghiên cứu khả năng kháng oxi hóa và gây độc tế bào ung thư của cao chiết ethanol từ tổ yến nuôi tại Việt Nam

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Tác giả: Thị Khoa Nguyễn, Thị Phương Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Nguyễn Tất Thành, 2023

Mô tả vật lý: tr.30

Bộ sưu tập: Metadata

ID: 339083

Thêm vào giỏ Liên kết toàn văn

Edible bird’s nest (EBN) is a well-known tonic food in Asian countries. Previous studies revealed that the aqueous extract of EBN exhibited remarkable pharmacological values such as antiviral, anti-inflammatory activities, osteoarthritic prevention and neural protection. However, the bioactivities of the EBN extracts in other solvents are still under investigation. In this study, we first determined the antioxidant and cytotoxic activities of the ethanol extract of farmed EBN in Viet Nam. The analysis of (2,2-diphenyl-1-picryl-hydrazyl-hydrate) (DPPH) assay showed that the ethanol extract considerably scavenged free radicals, IC50 = (94.74 ± 2.35) µg/mL. In addition, the ethanol extract exhibited significant cytotoxic activities against HuH-6 liver cancer cells, MCF-7 breast cancer cells and K562 leukemia cells with the IC50 values of (82.12 ± 2.42, 98.72 ± 2.50 và 53.70 ± 0.12) µg/mL, respectively. These results serve as a basis for further studies on the chemical constituents and the antioxidant and cytotoxic activities of the EBN ethanol extract in vivo models.Tổ yến (yến sào) là loại thực phẩm tăng cường sức khỏe nổi tiếng và có ý nghĩa kinh tế ở nhiều nước châu Á, trong đó có Việt Nam. Các nghiên cứu trước đây cho thấy tổ yến chiết bằng nước có tác dụng kháng virus, kháng viêm, ngăn ngừa viêm xương khớp và bảo vệ thần kinh. Tuy nhiên, những báo cáo về hoạt tính sinh học của cao chiết tổ yến bằng các dung môi khác vẫn còn hạn chế. Trong nghiên cứu này, chúng tôi bước đầu xác định một số hoạt tính sinh học của cao chiết ethanol từ tổ yến nuôi ở Việt Nam. Kết quả phân tích kháng oxi hóa sử dụng (2,2-diphenyl-1-picryl-hydrazyl-hydrate) (DPPH) cho thấy cao chiết này thể hiện hoạt tính kháng oxi hóa in vitro ở mức độ đáng kể IC50 = (94,74 ± 2,35) µg/mL. Đồng thời, cao chiết còn có khả năng gây độc tế bào ung thư gan HuH-6, ung thư vú MCF-7 và ung thư máu K562 với giá trị IC50 lần lượt là (82,12 ± 2,42, 98,72 ± 2,50 và 53,70 ± 0,12) µg/mL. Các kết quả thu được tạo cơ sở cho những nghiên cứu tiếp theo về thành phần hoạt chất cũng như hoạt tính kháng oxi hóa và gây độc tế bào ung thư của cao chiết ethanol từ tổ yến trên mô hình in vivo.

1. Đọc trực tuyến

1. Đọc trực tuyến

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