Nghiên cứu hiệu quả và an toàn của tiêm vi điểm Botulinum toxin so với Acid hyaluronic trong trẻ hóa da

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Tác giả: Thị Lệ Trang Dương, Trọng Hào Nguyễn, Trọng Hiến Nguyễn, Việt Thanh Phúc Nguyễn, Nguyên Ánh Tú Trần

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Thông tin xuất bản: Tạp chí Y Dược học Phạm Ngọc Thạch, 2023

Mô tả vật lý: tr.181

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ID: 339196

Thêm vào giỏ Liên kết toàn văn

- Mở đầu: Trong những năm gần đây, tiêm vi điểm botulinum toxin (BoNT) và acid hyaluronic (HA) được ứng dụng rộng rãi trong trẻ hóa da. Tuy nhiên chưa tìm thấy nghiên cứu nào so sánh hiệu quả trẻ hóa da của tiêm vi điểm botulinum toxin so với acid hyaluronic.- Mục tiêu: Nghiên cứu nhằm đánh giá hiệu quả và an toàn của tiêm vi điểm botulinum toxin so với acid hyaluronic trẻ hóa da tại Bệnh Viện Da Liễu Thành Phố Hồ Chí Minh.- Phương pháp nghiên cứu: Nghiên cứu quan sát mô tả trên 31 trường hợp được tiêm vi điểm nửa mặt bằng botulinum toxin và nửa mặt còn lại bằng acid hyaluronic không liên kết chéo. Dữ liệu ghi nhận dựa trên phân tích hình ảnh, chụp phân tích nếp nhăn bằng máy Visia, bảng câu hỏi khảo sát. Ghi nhận dữ liệu ở thời điểm trước khi tiêm và sau khi tiêm ở tuần 1, 2, 4, 8 và 12.- Kết quả: Tiêm vi điểm BoNT, HA không liên kết chéo an toàn. Các tác dụng không mong muốn xảy ra thoáng qua, không có sự khác biệt có ý nghĩa thống kê về tỷ lệ phản ảnh mức độ đau, vết đỏ do kim tiêm, sẩn phù, sưng bầm giữa 2 nhóm (p >
0.05). Các đối tượng tham gia nghiên cứu đều hài lòng với cả BoNT và HA. Mức độ hài lòng BoNT cao nhất ở tuần thứ 8, trong khi HA cao nhất ở tuần thứ 4. Mức độ hài lòng với BoNT luôn cao hơn HA, có ý nghĩa thống kê ở tuần thứ 8 (p <
0.001). Hiệu quả cải thiện nếp nhăn của HA cao nhất ở tuần thứ 1 (theo thang Glogau và GAIS) và ở tuần thứ 4 (theo máy phân tích da). Hiệu quả giảm nhăn BoNT kéo dài 12 tuần, đạt hiệu quả tối đa ở tuần thứ 2 (theo thang Glogau và GAIS) và ở tuần thứ 4 (theo máy phân tích da). Tiêm vi điểm BoNT cho hiệu quả cao hơn so với HA, kết quả có ý nghĩa thống kê ở tuần thứ 1, 2, 4 và 8 theo thang GAIS (p <
0.05), kết quả không có ý nghĩa thống kê theo thang Glogau và máy phân tích da (p >
0.05). - Kết luận: Tiêm vi điểm BoNT và HA không liên kết chéo có tính an toàn, tạo sự hài lòng cho bệnh nhân. Tiêm vi điểm HA phù hợp cho mong muốn hiệu quả nhanh trong khi tiêm vi điểm BoNT là lựa chọn ưu thế cho những người cần cải thiện nếp nhăn.Abstract- Background: Microinjection of botulinum toxin (BoNT) and hyaluronic acid (HA) is widely used for skin rejuvenation. However, no studies have been found to compare the effectiveness of wrinkle removal and skin rejuvenation of botulinum toxin microinjection compared to hyaluronic acid- Objectives To evaluate the efficacy and safety of hyaluronic acid and botulinum toxin microinjection in skin rejuvenation- Methods Descriptive observational study on 31 participants underwent one session where half the face was microinjected with botulinum toxin and the other half with non - crosslinked hyaluronic acid. The aesthetic outcomes were assessed at baseline and after 1, 2, 4, 8 and 12 weeks. Clinical evaluation was based on the Global Aesthetic Improvement Scale (GAIS), the Glogau’ scale and VISIA machine, survey questionnaire.- Results All a adverse effects were transient, there was no statistically significant difference in the rate of pain, needle redness, post - injection papules, bruising (p >
0.05). The study participants were satisfied with both BoNT and HA injections. BoNT satisfaction was highest at week 8, while HA was highest at week 4. Satisfaction level with BoNT is always higher than HA, which is statistically significant at week 8 (p <
0.001). The wrinkle improvement effect of HA was highest at week 1 (the Glogau and Gais scale) and at week 4 (skin analysis machine). BoNT wrinkle reduction effect lasts 12 weeks, maximum effect is achieved at week 2 (Glogau and Gais scale) and at week 4 (skin analysis machine). BoNT microinjection gives a higher effect than HA, the results are statistically significant at week 1, 2, 4 and 8 according to the Gais scale (p <
0.05), the results are not statistically significant according to the Glogau scale and skin analyzer (p >
0.05).- Conclusion Microinjection of BoNT and non cross-linked HA were safely. Study participants were satisfied with both injections. The effect of reducing small wrinkles of HA is faster but shorter than that of BoNT. HA microinjection is suitable for the desire for rapid effect. BoNT microinjection is the preferred choice for those who need to improve wrinkles. DOI: 10.59715/pntjmp.2.1.22

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