Đánh giá tương quan giữa điểm biến dạng hình đo bằng bảng M và cấu trúc hoàng điểm trong phù hoàng điểm do tắc tĩnh mạch võng mạc

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Quốc Tuấn Lê, Chí Hưng Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y Dược học Phạm Ngọc Thạch, 2023

Mô tả vật lý: tr.83

Bộ sưu tập: Metadata

ID: 339273

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- Mục đích nghiên cứu: Đánh giá mối liên quan giữa độ biến dạng hình đo bằng bảng M với cấu trúc hoàng điểm ở bệnh nhân tắc tĩnh mạch võng mạc. - Phương pháp: Đây là một nghiên cứu cắt ngang, khảo sát 57 bệnh nhân bị phù hoàng điểm do tắc tĩnh mạch võng mạc có thị lực logMAR chỉnh kính ≤ 1 và đang điều trị tại khoa Dịch Kính Võng Mạc BV Mắt TP.HCM từ 1/2018 đến 7/2018. Mối liên quan giữa độ biến dạng hình và các chỉ số của cấu trúc hoàng điểm trên chụp cắt lớp cố kết quang học (OCT) sẽ được xác định qua mô hình phân tích hồi quy tuyến tính.- Kết quả: Tuổi trung bình của mẫu nghiên cứu là 52,11 ± 10,56. Tỉ lệ nam và nữ lần lượt là 47,37% và 52,63%. Có 87,72% bệnh nhân đi khám vì lý do mờ mắt.Thời điểm đến khám trung bình là 33,05 ± 30,59 ngày. 73,68% bệnh nhân chưa điều trị tiêm nội nhãn. Tắc tĩnh mạch trung tâm chiếm 47,37%, tắc nhánh là 42,11% và tắc một nửa tĩnh mạch trung tâm là 10,53%. Có 42,11% bệnh nhân phù hoàng điểm dạng nang, 28,07% dày võng mạc lan tỏa, 17,54% bong võng mạc thanh dịch và 12,28% phù dạng nang kèm bong thanh dịch. Thị lực logMAR trung bình là 0,49 ± 0,28. Độ biến dạng hình trung bình là 0,50 ± 0,40 và hiện diện ở 82,46% bệnh nhân. Độ dày hố hoàng điểm trung tâm trung bình là 334,19 ± 76,14 µm. Độ dày võng mạc trung tâm 1 mm quanh hoàng điểm trung bình là 446,35 ± 158,03 µm.Thể tích vùng hoàng điểm trung bình là 11,52 ± 2,54 mm3. Thị lực logMAR có liên quan với các yếu tố: phù dạng nang, tổn thương màng giới hạn ngoài, nang võng mạc trong, nang võng mạc ngoài. Độ biến dạng hình M có liên quan với sự hiện diện nang võng mạc trong, nang võng mạc ngoài và tương quan tuyến tính có ý nghĩa thống kê với độ dày hố hoàng điểm trung tâm (r = 0,54, p <
0,0001), độ dày võng mạc trung tâm trong vòng 1 mm đường kính quanh hoàng điểm (r = 0,50, p <
0,0001), thể tích vùng hoàng điểm (r = 0,48, p = 0,0002).- Kết luận: Độ biến dạng hình trong phù hoàng điểm do tắc tĩnh mạch võng mạc có tương quan tuyến với các chỉ số cấu trúc hoàng điểm trên chụp cắt lớp cố kết quang học.Abstract- Purposes: To evaluate the correlation between metamorphopsia using M-CHARTS and foveal microstructure in patients with macular edema due to retinal vein occlusion.- Methods: This prospective cross - sectional study recruited 57 patients who had acute macular edema caused by retinal vein occlusion with logMAR BCVA ≤ 1 at the Vitreo - Retina Department of Ho Chi Minh City Eye Hospital in Vietnam from January to July in 2018. The correlation between metamorphopsia measured with M-CHARTS and foveal micro - structure indices on spectral - domain optical coherence tomography (SD-OCT) was investigated via linear regression analysis.- Results: The mean age of the research population was 52.11 ± 10.56. Prevalence of macular edema related to retinal vein occlusion in male and female patients was 47.37% và 52.63%, respectively. The mean duration of symptoms was 33.05 ± 30.59 days. 73.68% of patients have never been treated with anti - VEGF intravitreal injection. There were 47.37% of patients diagnosed with central retinal vein occlusion, 42.11 % with branch retinal vein occlusion and 10.53% with hemi - retinal vein occlusion. Mean logMAR BCVA was 0.49 ± 0.28. Metamorphopsia measured with M-CHARTS was 0.50 ± 0.40 on average and present in 82.46% of patients. Mean central foveal thickness (CFT) was 334.19 ± 76.14 µm, mean retinal thickness in the central 1 mm diameter area (CRT-1) 446.35 ± 158.03 µm, mean macular volume (MV) 11.52 ± 2.54 mm3. Metamorphopsia using M-CHARTS was significantly associated with the presence of inner and out retinal cysts. Linear regression analysis also revealed moderate correlation between metamorphopsia severity and CFT (r = 0.54, p <
0.0001), CRT-1 (r = 0.50, p <
0.0001) and MV (r = 0.48, p = 0.0002).- Conclusions: Metamorphopsia measured with M-CHARTS was statistically correlated with foveal micro - structure indices on SD-OCT in macular edema related to retinal vein occlusion. DOI: 10.59715/pntjmp.2.2.11

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