Hô hấp ký và nghiệm pháp đi bộ 6 phút ở bệnh nhân sau hồi phục Covid-19

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Tác giả: Sĩ Dũng Hồ, Thượng Dũng Hồ, Ngọc Vân Hoàng, Đình Thanh Lê, Thị Điệp Lê, Thế Hoàng Ngô, Đức Công Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y Dược học Phạm Ngọc Thạch, 2023

Mô tả vật lý: tr.176

Bộ sưu tập: Báo, Tạp chí

ID: 339302

Thêm vào giỏ Liên kết toàn văn

- Mục tiêu: Đánh giá hô hấp ký (HHK) và khoảng cách đi bộ 6 phút ở các bệnh nhân đã hồi phục sau COVID-19 và mối liên quan với độ nặng của nhiễm COVID-19 và hình ảnh xơ phổi.- Đối tượng và phương pháp: Cắt ngang mô tả kết trên 86 trường hợp (32 nam và 54 nữ, tuổi trung bình 53,2 ± 11,6, BMI 26,7 ± 6,2 kg/m2) được xác nhận COVID-19 đã hồi phục. Bệnh nhân được đánh giá bằng phương pháp đo HHK (FVC, FEV1, FEV1/ FVC, FEF 25 - 75 và PEF) và nghiệm pháp đi bộ 6 phút (ĐB6P) từ 3 đến 6 tháng sau khi xuất hiện các triệu chứng nhiễm COVID-19.- Kết quả: HHK bất thường 37,2% (32 trường hợp), với 13,9% hội chứng tắc nghẽn và 23,3% hội chứng hạn chế, trong đó hội chứng hạn chế phần lớn xảy ra ở nhóm viêm phổi nặng (92,3%) (p = 0,001). Khoảng cách trung bình đi bộ 6 phút có xu hướng ngắn hơn ở nhóm viêm phổi nặng 409,5 ± 54,6m, nhưng khác biệt không có ý nghĩa thống kê giữa 3 nhóm theo độ nặng khi mắc COVID-19 (p = 0,126). Hai mươi hai bệnh nhân (25,6%) có xơ phổi tồn lưu, thường gặp ở nhóm viêm phổi nặng (66,2%) (p = 0,023).- Kết luận: Hơn một phần ba bệnh nhân có bất thường HHK sau COVID-19. Viêm phổi nặng do COVID-19 gây hội chứng hạn chế và xơ phổi tồn lưu cao hơn khi so sánh với những bệnh nhân ở các nhóm có triệu chứng và viêm phổi nhẹ và trung bình.Abstract- Objective: Study of spirometry and six - minute walking distance result in patients who have recovered from COVID-19.- Methods: Descriptive cross - section on 86 cases (32 males and 54 females, mean age 53.2 ± 11.6, BMI 26.7 ± 6.2 kg/m2) confirmed COVID-19 recovery. Patients were evaluated by spirometry (FVC, FEV1, FEV1/FVC, FEF 25 - 75, and PEF) and a six - minute walk test (6MWT) 3 to 6 months after the onset of COVID-19 symptoms.- Results: Abnormal respiratory function rate was 37.2% (32 cases) with 13.9% obstructive spirometry pattern and 23.3% restrictive spirometric pattern. Restrictive pattern mostly occurred in the severe pneumonia group (92.3%) (p = 0.001). The mean walking distance of 6 minutes was shorter in the group with severe pneumonia (409.5 ± 54.6m), but the difference was not statistically significant between three groups (p = 0.126). Twenty - two patients (25.6%) had pulmonary fibrosis, which was common in the severe pneumonia group (66.2%) (p = 0.023).- Conclusion: More than a third of patients had abnormal respiratory function after COVID-19. Severe pneumonia caused by COVID-19 was associated with a higher prevalence of restrictive spirometric pattern and pulmonary fibrosis when compared with patients in mild and moderate pneumonia groups. DOI: 10.59715/pntjmp.2.2.22

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