Tổng quan về triệu chứng lâm sàng và điều trị hội chứng Steven Johnson ở mắt

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Hoàng Long Đặng, Ngọc Vân Anh Lê, Thị Tú Cúc Phan

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y Dược học Phạm Ngọc Thạch, 2023

Mô tả vật lý: tr.42

Bộ sưu tập: Metadata

ID: 339309

Thêm vào giỏ Liên kết toàn văn

Hội chứng Steven Johnson và hoại tử biểu bì nhiễm độc là các biến thể khác nhau của cùng một phổ bệnh lý gây ra do phản ứng qua trung gian miễn dịch, đặc trưng trong giai đoạn cấp bởi hoại tử và bong lớp thượng bì lan tỏa. Triệu chứng tại mắt xuất hiện hầu hết trường hợp, đều nặng và có thể dẫn đến mù lòa do tổn thương giác mạc nhưng thường bị bỏ qua và điều trị muộn. Điều trị trong giai đoạn cấp tính là cấp thiết nhằm giảm nhẹ mức độ nặng của di chứng trong giai đoạn mạn tính. Tuy nhiên, biến chứng mạn tính vẫn có thể xảy ra dù đã điều trị tích cực ở giai đoạn cấp tính. Tiến bộ trong giai đoạn cấp tính và mạn tính như ghép màng ối, ghép giác mạc nhân tạo và ghép biểu mô niêm mạc miệng mang lại hiệu quả cao trong việc bảo tồn thị lực và ngăn ngừa tổn thương bề mặt nhãn cầu. Bài tổng quan này mô tả triệu chứng lâm sàng và việc điều trị hội chứng Steven - Johnson tại mắt nhằm giúp bệnh nhân bảo tồn được thị lực và cải thiện chất lượng sống.Abstract Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which are represented by different ends of the spectrum of an immune - mediated disease, are characterized in the acute phase followed by intraepidermal cell necrosis and detachment. Ocular involvement which occurs in the vast majority of cases, issevere andcan lead to corneal blindness. Howerver, it is often overlooked and itstreatment is delayed. Treatment in the acute phase is imperative in mitigating the severity of ocular sequelae in chronic phase. However, severe chronic complicationscan still occur even with aggressiveacute treatment. Advances in acute and chronic treatment such as amniotic membrane transplantation (AMT), keratoprosthesis and cultivated autologous oral mucosal epithial - plus amniotic membrane transplantation (COMET) have shown tobe effective in preserving vision and reduce risk of ocular surface failure. However, severe chronic complicationscan still occur even with aggressiveacute treatment. This review describes the acute and chronic findings in SJS/TEN and discusses management strategies, so that patients preserve vision and improve quality of life. DOI: 10.59715/pntjmp.1.2.5

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR