Liên quan giữa nhiễm mỡ và xơ hóa gan với độ dày lớp nội trung mạc động mạch cảnh ở bệnh nhân bệnh gan nhiễm mỡ không do rượu

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Tác giả: Minh Khuê Đàm, Thị Khánh Tường Trần

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y Dược học Phạm Ngọc Thạch, 2023

Mô tả vật lý: tr.22

Bộ sưu tập: Metadata

ID: 339333

Thêm vào giỏ Liên kết toàn văn

- Đặt vấn đề: Bệnh gan nhiễm mỡ không do rượu (Non - alcoholic Fatty Liver Disease: NAFLD) là bệnh lý gan mạn phổ biến trên thế giới với tỉ lệ hiện mắc là gần 30%. Nhiều nghiên cứu đã chứng minh có mối liên hệ giữa NAFLD và gia tăng độ dày lớp nội trung mạc động mạch cảnh (ĐDLNTMĐMC). Từ đó, góp phần gián tiếp chứng minh được sự liên quan giữa NAFLD và các yếu tố nguy cơ tim mạch. Trên thế giới, đây là một vấn đề tương đối mới và hiện vẫn còn nhiều nghiên cứu đang thực hiện. Ở Việt Nam, mới chỉ có một vài đề tài về sự liên quan của NAFLD với bệnh tim mạch. Chính vì vậy, chúng tôi quyết định thực hiện đề tài “Liên quan giữa nhiễm mỡ và xơ hóa gan với độ dày lớp nội trung mạc động mạch cảnh ở bệnh nhân bệnh gan nhiễm mỡ không do rượu” để góp phần làm sáng tỏ vấn đề trên.- Phương pháp: Nghiên cứu cắt ngang thực hiện tại phòng khám đa khoa trường đại học Y Khoa Phạm Ngọc Thạch và phòng khám Hòa Hảo từ 01/2020 đến 6/2020. Bệnh nhân có gan nhiễm mỡ trên siêu âm thỏa tiêu chuẩn nghiên cứu được thực hiện đo FibroScan và đo ĐDLNTMĐMC. Xử lý số liệu bằng phần mềm SPSS 20.- Kết quả: Nghiên cứu khảo sát được 145 bệnh nhân từ tháng 01/2020 đến tháng 6/2020. Qua phương pháp đo Fibroscan-CAP và đo ĐDLNTMĐMC, chúng tôi ghi nhận được giá trị trung bình của ĐDLNTMĐMC ở hai bên của bốn mức độ nhiễm mỡ gan đều là 0,6mm và của bốn mức độ xơ hóa gan đều là 0,6 mm, riêng F3 là 0,7mm. Không có mối tương quan thuận giữa chỉ số nhiễm mỡ gan và xơ hóa gan trên Fibroscan-Cap với ĐDLNTMĐMC.- Kết luận: Giá trị trung bình của ĐDLNTMĐMC ở hai bên của bốn mức độ nhiễm mỡ gan trên Fibroscan-CAP là gần bằng nhau, không có sự khác biệt có ý nghĩa thống kê và không có sự liên quan giữa chỉ số nhiễm mỡ gan và xơ hóa gan trên Fibroscan-CAP với ĐDLNTMĐMC.Abstract- Background/Aims: Nowadays, nonalcoholic fatty liver disease (NAFLD) affects almost 30 percent of the general population in various countries. Many studies have proved that there are correlations between NAFLD and the increase of carotid intima - media thickness (CIMT). Therefore, they can be an indirect evidence for the correlations between NAFLD and cardiovascular risk factors. This is still a new topic in the world and many studies are still being carried out. In Vietnam, there is just only one study about the correlation between NAFLD and cardiovascular diseases. As a result, we had decided to conduct the study namely “Correlations between fatty, fibrosis liver and carotid intima-media thickness in patient with non-alcoholic fatty liver disease” in order to clarify the aformentioned topic.- Methods: A cross - sectional study was carried out at Polyclinic of Pham Ngoc Thach university of medicine and Hoa Hao clinic from January 2020 to June 2020. Patients with fatty liver disease on ultrasound who met the study criteria had been then received FibroScan and carotid intima-media thickness measurement. Data processed by SPSS 20 software.- Results: 145 patients were included in the study from January 2020 to June 2020. By measuring the level of fatty liver via Fibroscan and measuring the CIMT, we observed that the mean CIMT values on both sides of NAFLD patients in four different level of fatty and fibrosis liver are 0.6mm, only the mean CIMT of patients in level fibrosis F3 is 0.7mm. There is no correlation between levels of fatty liver as well as levels of liver fibrosis and CIMT.- Conclusions: The mean CIMT values on both sides of patients in four different level of fatty liver measuring by Fibroscan are almost the same, there is no difference between levels of fatty liver as well as levels of liver fibrosis and CIMT. DOI: 10.59715/pntjmp.1.3.3

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