Tỷ lệ và một số đặc điểm bệnh gan nhiễm mỡ liên quan chuyển hóa ở bệnh nhân bị gan nhiễm mỡ tại Bệnh viện Nhân Dân Gia Định

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Tác giả: Ngọc Tường Vy Nguyễn, Quốc Bảo Vũ

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Y Dược học Phạm Ngọc Thạch, 2023

Mô tả vật lý: tr.118

Bộ sưu tập: Metadata

ID: 339345

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- Đặt vấn đề: Bệnh gan nhiễm mỡ liên quan chuyển hóa (BGNMLQCH) là một bệnh lý phổ biến, có thể làm tăng nguy cơ nhiều bệnh lý khác như tim mạch, đái tháo đường, ung thư gan, xơ gan.- Mục tiêu: Nghiên cứu này nhằm khảo sát tỷ lệ bệnh nhân BGNMLQCH và một số đặc điểm lâm sàng, cận lâm sàng ở bệnh nhân có gan nhiễm mỡ. - Đối tượng - Phương pháp: Đây là nghiên cứu cắt ngang mô tả trên 65 bệnh nhân gan nhiễm mỡ khám tại bệnh viện Nhân Dân Gia Định. Các đặc điểm nhân trắc, lâm sàng, cận lâm sàng, đo độ đàn hồi thoáng qua được ghi nhận. BGNMLQCH được xác định khi có gan nhiễm mỡ kèm với ít nhất 1 trong 3 tiêu chuẩn: thừa cân - béo phì hoặc đái tháo đường hoặc hội chứng rối loạn chuyển hóa.- Kết quả: Tỷ lệ BGNMLQCH trong số bệnh nhân có gan nhiễm mỡ là 85,1%. Tuổi trung bình của nhóm BGNMLQCH là 56,1 ± 13,6 tuổi. Tỷ lệ nam là 49,1%. Tỷ lệ BGNMLQCH có kèm tăng huyết áp, rối loạn chuyển hóa mỡ máu, đái tháo đường, béo phì trung tâm lần lượt là 64,2%, 96,2%, 26,4% và 90,6%. CAP trung bình là 299 ± 44,9 dB/m. Gan nhiễm mỡ nặng chiếm 66%. Độ đàn hồi có trung vị là 6,4 (5,0
9,5). Xơ hóa gan đáng kể trở lên chiếm 36%, trong đó, xơ gan chiếm 12%. - Kết luận: Phần lớn bệnh nhân có gan nhiễm mỡ đạt đủ tiêu chuẩn BGNMLQCH, chiếm 85,1%. Tỷ lệ BGNMLQCH có kèm tăng huyết áp, rối loạn chuyển hóa mỡ máu, béo phì trung tâm chiếm tỷ lệ cao, lần lượt là 64,2%, 96,2% và 90,6%. Gan nhiễm mỡ nặng chiếm 66% số trường hợp. Xơ hóa gan đáng kể trở lên chiếm 36%.Abstract- Introduction: Metabolic - assocciated fatty liver disease (MAFLD) is a common disorder that could increase the risk of many other diseases such as cardiovascular disease, diabetes, hepatocellular carcinoma, cirrhosis. - Objectives: This study aims to investigate the proportion of MAFLD and some clinical, paraclinical characteristics in patients with fatty liver. - Materials - Methods: This is a descriptive cross - sectional study on 65 fatty liver patients at Gia Dinh People’s Hospital. Anthropometric, clinical, laboratory, and transient elastography characteristics were recorded. Diagnosis of MAFLD is based on the detection of liver steatosis together with the presence of at least one of three criteria that includes: overweight - obesity or diabetes or clinical evidence ofmetabolic dysfunction. - Results: The rate of MAFLD among the patients with fatty liver was 85.1%. The mean age of the MAFLD group was 56.1 ± 13.6 years old. The percentage of men was 49.1%. The rates of MAFLD with hypertension, dyslipidemia, diabetes, and central obesity were 64.2%, 96.2%, 26.4% and 90.6%, respectively. The average CAP was 299 ± 44.9 dB/m. The rate of severe fatty liver was 66%. The medianelasticity of the liver was 6.4 (5.0
9.5). The rate of significant liver fibrosis was 36%, including 12% of cirrhosis. - Conclusions: Marjority of the patients with fatty liver was MAFLD, 85.1%. The rates of MAFLD with hypertension, dyslipidemiaand central obesity were high, 64.2%, 96.2%, 26.4% and 90.6%respectively. The rate of severe fatty liver was 66%. The rate of significantliver fibrosis was 36%. DOI: 10.59715/pntjmp.1.3.15

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