Đặc điểm và các yếu tố liên quan của tình trạng rối loạn chức năng tuyến giáp ở trẻ sinh non dưới 34 tuần tuổi thai tại Bệnh viện Nhi Đồng 2

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Thị Bích Tuyền Hồ, Thị Diễm Thúy Hoàng, Thanh Thiện Nguyễn, Thị Kim Anh Nguyễn, Thúc Bội Ngọc Nguyễn, Tố Na Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Y Dược học Phạm Ngọc Thạch, 2023

Mô tả vật lý: tr.125

Bộ sưu tập: Metadata

ID: 339346

Thêm vào giỏ Liên kết toàn văn

- Đặt vấn đề: Hormone giáp đóng vai trò quan trọng trong sự trưởng thành và phát triển của não bộ. Rối loạn chức năng tuyến giáp thường gặp ở trẻ non tháng và có thể bị ảnh hưởng trong quá trình điều trị bệnh lý của trẻ sinh non.- Mục tiêu: Xác định tỉ lệ bị rối loạn chức năng tuyến giáp cần điều trị hormone giáp và các yếu tố liên quan ở trẻ sinh non dưới 34 tuần tuổi thai tại bệnh viện Nhi Đồng 2.- Đối tượng - Phương pháp nghiên cứu: Cắt ngang mô tả có phân tích, tiến cứu, sàng lọc chức năng tuyến giáp cho 262 trẻ sinh non dưới 34 tuần tuổi thai ít nhất 2 lần.- Kết quả: Có 16 ca (6,1%) bị rối loạn chức năng tuyến giáp cần điều trị hormone giáp. Tỉ lệ nam/nữ = 3/1
tuổi thai trung bình 30,5 ± 2,5 (26 - 34 tuần)
cân nặng lúc sinh trung bình 1496 ± 525 (800 - 2600 gram). Các bệnh lý đi kèm sinh non là viêm phổi 75%
bệnh màng trong 56,2%
nhiễm trùng huyết 75%
còn ống động mạch 37,5%
viêm màng não 18,8%
dị tật bẩm sinh 37,5%
vàng da ứ mật 12,5%
xuất huyết não 12,5%
viêm ruột hoại tử 12,5%. Giá trị trung bình xét nghiệm TSH và FT4 lần đầu 61,16 ± 35,62 mU/L và 0,82 ± 0,25 ng/dL
lần hai 58,06 ± 26,77 mU/L và 0,81 ± 0,20 ng/dL
lần ba 31,45 ± 12,94 mU/L và 0,96 ± 0,38 ng/dL. Các yếu tố có liên quan đến rối loạn chức năng tuyến giáp cần điều trị là sinh ngạt, dị tật bẩm sinh, phẫu thuật và iod.- Kết luận: Cần sàng lọc chức năng tuyến giáp ở trẻ sinh non ít nhất hai lần để tránh bỏ sót suy giáp. Abstract- Backgrounds: Thyroid hormones are critical for growth and brain development during the newborn period and infancy. Thyroid dysfunction is common in preterm infants and may be affected during the treatment of comorbidities associated with preterminfants.- Objective: To identifythe proportionof thyroid dysfunction requiring levothyroxine treatmentand its related factors in preterm infants born before 34 gestational weeks at Children’s Hospital 2.- Methods: A prospective cross-section study, screening at least 2 times thyroid functions of 262 preterm infants born before 34 gestational weeks. - Results: Sixteen cases (6.1%) with thyroid dysfunctions requiring levothyroxine treatments. The ratio between male/female = 3:1, the mean postnatal age was 30.5 ± 2.5 (26 - 34 weeks), the mean birthweightwas 1496 ± 525 (800 - 2600 gram). The comorbidities associated with preterminfants such as pneumonia (75%), respiratory distress syndrome (56.2%), sepsis (75%), patent ductus arteriosus (37.5%), meningitis (18.8%), birth defects (37.5%), cholestatic jaundice (12.5%), cerebral haemorrhage (12.5%), necrotizing enterocolitis (12.5%). The mean value of initial TSH and FT4 tests were 61.16 ± 35.62 mU/L and 0.82 ± 0.25 ng/dL, the second were 58.06 ± 26.77 mU/L and 0.81 ± 0.20 ng/dL, and the third were 31.45 ± 12.94 mU/L and 0.96 ± 0.38 ng/dL. The risk factors associated with thyroid dysfunction requiring levothyroxine treatmentare statistically significant such as birth asphyxiation, birth defects, surgery, and iodine.- Conclusions: Screening thyroid functions at least two times is neededin preterm infants in order to prevent missing hypothyroidism. DOI: 10.59715/pntjmp.1.3.16

1. Đọc trực tuyến

1. Đọc trực tuyến

Tạo bộ sưu tập với mã QR