TÁC DỤNG HẠ GLUCOSE HUYẾT, ĐIỀU HÒA HOẠT TÍNH ENZYME GLUCOSE-6-PHOSPHATASE VÀ KHÁNG OXY HÓA IN VIVO CỦA CAO CHIẾT RỄ CÂY GÁO VÀNG (Nauclea orientalis L.)

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Tác giả: Thị Xuân Trang Đái, Thị Hồng Tơ Lê, Thị Kim Xuyến Nguyễn, Kim Định Phan, Chí Linh Trần

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2023

Mô tả vật lý: tr.109-117

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ID: 339638

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Mục tiêu của nghiên cứu này là xác định hoạt động của malondialdehyde, glutathione và glucose-6-phosphatase trong gan, thận và tuyến tụy của chuột mắc bệnh đái tháo đường được điều trị bằng cao chiết rễ cây gáo vàng. Ngoài ra, nghiên cứu cũng đánh giá hoạt tính kháng oxy hóa và ức chế enzyme (α-amylase, α-glucosidase) của cao rễ gáo vàng. Sự tăng glucose huyết được gây ra ở chuột bằng cách sử dụng alloxan monohydrate (135 mg/kg). Chuột tăng glucose huyết được điều trị bằng cao rễ gáo vàng (100, 200, 400 mg/kg khối lượng/ hai lần một ngày). Glucophage được sử dụng như một chất đối chứng dương với liều 108 mg/kg khối lượng/ hai lần một ngày. Chuột được cho uống với Glucophage hoặc cao rễ gáo vàng trong 21 ngày. Việc bổ sung cao rễ gáo vàng hoặc Glucophage làm giảm đáng kể hàm lượng glucose trong máu
ức chế sự gia tăng của malondialdehyde và tăng hoạt động của glutathione trong tuyến tụy, gan và thận của chuột mắc bệnh đái tháo đường. Bên cạnh đó, kết quả cũng đã chứng minh rằng rễ gáo vàng làm giảm hoạt động của enzyme glucose-6-phosphatase.The present study aimed to estimate the activities of malondialdehyde, glutathione and glucose-6-phosphatase in the pancreas, liver and kidneys of diabetic mice treated by extracts of Nauclea orientalis L. roots. In addition, this study evaluated the antioxidant activity and marker enzymes inhibitory (α-amylase
α-glucosidase) of the Nauclea orientalis L. roots extract. Hyperglycemia was induced in mice by administration of alloxan monohydrate (135 mg/kg, ip.). Hyperglycemic mice were treated with the extract of Nauclea orientalis L. roots (100, 200, 400 mg/kg body weight/ twice a day). Glucosephage was used as a possitive control agent with dose of 108 mg/kg body weight/twice a day. The experimental mice were administered with both Glucophage and Nauclea orientalis L. roots extract orally during 21 days. The treatment of Nauclea orientalis L. roots and Glucophage significantly decreased the blood glucose levels
suppressed the abnormal elevations of malondialdehyde levels and increased the activity of glutathione in the pancreas, liver and kidneys of diabetic mice. Besides, the results proved that the extracts of Nauclea orientalis L. roots also managed the excessive activity of glucose-6-phosphatase.

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