DIỆP HẠ CHÂU CẢI THIỆN BỆNH SỎI THẬN DO CALCIUM OXALATE GÂY RA THÔNG QUA KHÁNG OXY HÓA VÀ KHÁNG VIÊM

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Tác giả: Hồng Phiến Huỳnh, Thanh Mến Trần

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2023

Mô tả vật lý: tr.262-269

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ID: 339766

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Tác dụng của các hợp chất có hoạt tính sinh học trong thực vật được thể hiện dựa trên khả năng chống oxy hóa, giúp giảm thiểu tác hại gây ra bởi các gốc tự do sinh ra từ quá trình hình thành và phát triển sỏi niệu. Chiết xuất diệp hạ châu chứa một lượng lớn chất chống oxy hóa có thể đóng vai trò quan trọng trong việc hấp phụ và trung hòa các gốc tự do. Hoạt tính chống oxy hóa này phần lớn có thể là do thành phần phenolic và flavonoid có chứa trong thực vật với hàm lượng lần lượt là 438,13±16,37 (mg GAE/g cao chiết) và 157,10±1,31 (mg QE/g cao chiết). Khả năng kháng oxy hóa được đánh giá qua 4 phương pháp DPPH, ABTS, RP, TAC với giá trị EC50 lần lượt là 129,74±3,05
82,35±1,25
196,03±6,66 và 40,32±2,78 µg/mL. Cao chiết diệp hạ châu giúp giảm biến tính protein albumin huyết thanh bò với IC50 là 1,52±0,28 mg/mL, thấp hơn 7,24 lần so với chất chuẩn diclofenac (0,21± 0,08 mg/mL). Sự tạo mầm của tinh thể calcium oxalate bị ức chế bởi chiết xuất từ diêp hạ châu với IC50 là 4,74±0,31 mg/mL. Những kết quả này cho thấy diệp hạ châu có thể xem là một dược liệu tiềm năng để điều trị sỏi tiết niệu.The effects of bio-active compounds in plants are shown to be based on their antioxidant capacity, which helps to reduce the damage caused by free radicals generated from the formation and development of urinary stones. Phyllanthus amarus extract contains a large amount of antioxidants that can play an important role in the adsorption and neutralization of free radicals. This antioxidant activity can largely be attributed to the phenolic and flavonoid components contained in the plant with concentrations of 438.13±16.37 (mg GAE/g extract) and 157.10±1.31 (mg QE/g extract), respectively. Oxidation resistance was evaluated through 4 methods DPPH, ABTS, RP, TAC, with EC50 values of 129.74±3.05
82.35±1.25
196,03±6.66 and 40.32±2.78 µg/mL, respectively. Phyllanthus amarus extract reduced the denaturation of bovine serum albumin protein with an IC50 of 1.52±0.28 mg/mL, 7.24 times lower than that of the standard diclofenac (0.21± 0.08 mg/mL). The nucleation of calcium oxalate crystals was inhibited by the extract of Phyllanthus amarus with IC50 of 4.74±0.31 mg/mL. These results suggest that Phyllanthus amarus can be considered as a potential medicinal plant for the treatment of urinary stones.

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