ĐÁNH GIÁ HOẠT TÍNH SINH HỌC CỦA CAO CHIẾT LIỄU (SALIX BABYLONICA) THU TẠI THÁI NGUYÊN

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Tác giả: Phú Hiệp Hoàng, Hồng Chuyên Phạm, Văn Khang Phạm, Quang Trung Từ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2023

Mô tả vật lý: tr.348-353

Bộ sưu tập: Metadata

ID: 339831

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Liễu (Salix Babylonica) là cây thân gỗ, cây bụi phân bố rộng rãi ở Châu Phi, Bắc Mỹ, Châu Âu và Châu Á. Loài này được sử dụng trong y học dân gian và có nhiều các chất có hoạt tính sinh học, trong đó có salicin, một tiền chất của axit salicylic. Trong nghiên cứu này, 500 g cao ethanol chiết xuất từ 6kg lá Liễu tươi bằng phương pháp chiết hồi lưu được xác định thành phần hóa học và đánh giá hoạt tính kháng khuẩn, hoạt tính chống oxy hóa. Kết quả cho thấy, trong cao chiết ethanol của lá Liễu có các nhóm phenolic, alkaloid, saponin, flavonoid, coumarin, steroid. Cao chiết ethanol của lá Liễu có hoạt tính oxy với giá trị IC50 trung bình là 5,65 µg/ml. Cao chiết ethanol Liễu có khả năng kháng khuẩn mạnh nhất với các chủng vi khuẩn Gram dương như Staphylococcus aureus. Đối với các vi khuẩn Gram âm như Pseudomonas aeruginosa và Citrobacter freundii, hoạt tính kháng khuẩn kém hơn. Kết quả nghiên cứu cho thấy tiềm năng của cây Liễu có thể thay thế kháng sinh trong phòng trị bệnh do vi khuẩn gây ra ở người.Willows (Salix babylonica) are trees and shrubs that are widely distributed in Africa, North America, Europe, and Asia. This species is used in folk medicine and contains many biologically active substances, including salicin, a precursor of salicylic acid. In this study, we extracted 500g of ethanol extract from 6kg of fresh willow leaves using the reflux extraction method to determine its chemical composition and evaluate its antibacterial and antioxidant activities. The results showed that the ethanol extract of willow leaves contains phenolic, alkaloid, flavonoid, coumarin, and steroid groups. It also exhibits high antioxidant activity, with an average IC50 value of 5.65 µg/ml. Moreover, the ethanol extract of willow leaves exhibits strong antibacterial activity, especially against Gram-positive bacteria such as Staphylococcus aureus. However, its antibacterial activity against Gram-negative bacteria such as Pseudomonas aeruginosa and Citrobacter freundii is comparatively weaker. These research findings highlight the potential of willow trees as a natural alternative to antibiotics in the treatment of bacterial diseases in humans.

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