ĐÁNH GIÁ SO SÁNH HOẠT TÍNH KHÁNG KHUẨN VÀ KHÁNG NẤM CỦA CÁC DẠNG BÀO CHẾ ION KIM LOẠI

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Tác giả: Khánh Phương Đặng, Thị Hà Liên Nghiêm, Hà Nhung Nguyễn, Thị Kiều Oanh Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2023

Mô tả vật lý: tr.53-58

Bộ sưu tập: Metadata

ID: 339902

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The threat posed by antibiotic resistance has become particularly critical in recent years because multiple and extended resistant bacteria have become more prevalent, leading to more common hard-to-treat infections worldwide. There is an urgent need to develop new antimicrobial agents against drug-resistant strains. The present study aims to investigate the potential of the new formulations including silver (I) nanoparticles as well as copper (II) and zinc (II) chelates in their separated and complex forms in the treatment of infectious diseases. The capacity of metallic ion based systems to suppress the development of microorganism often seen on wounds, such as Gram-negative bacteria (Klebsiella pneumonia ATCC 700603, Pseudomonas aeruginosa ATCC 27853), Gram-positive bacteria (Staphylococcus aureus ATCC 29213), and fungi (Candida albicans ATCC 10231) were evaluated by microdilution assay. We showed the inhibition percentage against each bacterial strain, which can be used to calculate the minimum inhibitory concentration (MIC) of these metal ions formulations. The positive results suggested that these formulas thus could be developed for wound care in therapy.Tình trạng kháng thuốc kháng sinh là một tình trạng đáng báo động trên toàn thế giới trong những năm gần đây do các vi khuẩn siêu kháng thuốc xuất hiện ngày càng phổ biến và làm cho các bệnh truyển nhiễm trở nên khó điều trị hơn. Điều này đặt ra nhu cầu cấp thiết cần nghiên cứu và phát triển ra các thuốc kháng khuẩn - nấm đối phó với tình trạng kháng thuốc. Nghiên cứu của chúng tôi nhằm mục đích đánh giá khả năng của nano bạc (I) cũng như phức đồng (II) và phức kẽm (II) thế hệ mới ở dạng riêng biệt và kết hợp trong điều trị các bệnh nhiễm trùng. Khả năng của nano kim loại và phức kim loại trong việc tiêu diệt các vi khuẩn thường xuyên xuất hiện trên các vết thương như các vi khuẩn Gram âm (Klebsiella pneumonia ATCC 700603 và Pseudomonas aeruginosa ATCC 27853), vi khuẩn Gram dương (Staphylococcus aureus ATCC 29213), và nấm (Candida albicans ATCC 10231) được đánh giá bằng phương pháp vi pha loãng. Chúng tôi đã chỉ ra phần trăm ức chế vi sinh vật của các công thức bào chế ion kim loại và tính toán được nồng độ ức chế tối thiểu của các chế phẩm này. Kết quả khả quan của nghiên cứu này cho thấy rằng các dạng bào chế ion kim loại có thể được phát triển thành các sản phẩm chăm sóc vết thương ứng dụng trong trị liệu.

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