ĐÁP ỨNG MIỄN DỊCH TRUNG HOÀ Ở HEO CAI SỮA SAU TIÊM VẮC XIN LỞ MỒM LONG MÓNG

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Tác giả: Ngọc Hải Nguyễn, Thị Kiều Oanh Võ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2023

Mô tả vật lý: tr.87-94

Bộ sưu tập: Báo, Tạp chí

ID: 339909

Thêm vào giỏ Liên kết toàn văn

PD50 của vắc xin Lở mồm long móng là chỉ số xác định liều kháng nguyên vắc xin có hiệu quả bảo hộ được 50% vật nuôi được tiêm vắc xin chống lại sự công độc virus Lở mồm long móng độc lực cao. Vắc xin Lở mồm long móng có 2 loại: vắc xin tiêu chuẩn (>
3PD50) và vắc xin có đáp ứng cao (>
6PD50). Vắc xin Lở mồm long móng >
6PD50 ngoài khả năng tạo đáp ứng miễn dịch nhanh, mạnh và kéo dài hơn so với vắc xin Lở mồm long móng >
3PD50, còn có thể nâng cao hiệu quả bảo hộ của vắc xin đối với các chủng virus khác topotype. Nghiên cứu nhằm so sánh đáp ứng miễn dịch ở heo đối với 2 loại vắc xin Lở mồm long móng >
3PD50 và >
6PD50, dựa trên hiệu giá kháng thể trung hoà, để làm rõ sự khác biệt về hiệu quả bảo hộ của 2 loại vắc xin đối với các chủng virus Lở mồm long móng phân lập tại Việt Nam, phục vụ cho việc sử dụng vắc xin trong phòng bệnh Lở mồm long móng. Kết quả cho thấy có sự khác biệt về hiệu quả tạo miễn dịch giữa 2 loại vắc xin Lở mồm long móng >
6PD50 và >
3PD50. Heo được tiêm vắc xin Lở mồm long móng >
6PD50 có tỉ lệ mẫu dương tính và hiệu giá kháng thể trung hoà đối với các chủng virus Lở mồm long móng thuộc topotype O/ME-SA/PanAsia, O/SEA/Mya 98 và O/ME-SA/Ind 2001e, phân lập tại Việt Nam, đều cao hơn có ý nghĩa thống kê so với heo được tiêm vắc xin Lở mồm long móng >
3PD50 (P<
0,05). Vắc xin Lở mồm long móng >
6PD50 có thể tạo được miễn dịch trung hoà cao, vượt qua được sự khác biệt về topotype của các chủng virus Lở mồm long móng. Kết quả nghiên cứu là cơ sở tham khảo cho việc sử dụng vắc xin trong phòng bệnh Lở mồm long móng.PD50 of Foot-and-mouth disease (FMD) vaccine is a dose-determining index of vaccine antigen that protects 50% of vaccinated animals against a challenge with virulent FMD virus. FMD vaccines classified into standard potency FMD vaccine (>
3PD50) and higher potency vaccine>
6PD50). The FMD >
6PD50 vaccine, in addition to its ability to induce a faster, stronger and longer lasting immune response than the FMD >
3PD50 vaccine, can also enhance the protective effect against FMDV strains of different topotypes. The study aimed to compare the immune response in pigs to 2 types of Foot-and-mouth disease vaccines >
3PD50 and >
6PD50, based on neutralizing antibody titers, to clarify the difference in the protective efficacy of the two vaccines to the foot-and-mouth disease virus strains isolated in Vietnam, serving the use of vaccines in the prevention of Foot-and-mouth disease. The results showed that there is a difference in immunogenicity between the two FMD vaccines, >
6PD50 and >
3PD50. Pigs vaccinated with FMD >
6PD50 had a positive rate and neutralizing antibody titer against FMD virus strains belonging to the topotype O/ME-SA/PanAsia, O/SEA/Mya 98 and O/ME-SA/Ind 2001e, isolates in Vietnam, were statistically significantly higher than pigs vaccinated with FMD 3PD50 (P<
0.05). FMD vaccine with a high PD50 value (>
6PD50) can induce high neutralizing immunity, overcoming the differences in the topology of FMD virus field and vaccine strains. The result of the study could be used for vaccination to control FMD.

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