NGHIÊN CỨU ĐẶC ĐIỂM THỰC VẬT VÀ HOẠT TÍNH SINH HỌC CỦA CÂY THIÊN NIÊN KIỆN LÁ LỚN (HOMALOMENA PENDULA)

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Tác giả: Quốc Tuấn Đoàn, Đình Quỳnh Phú Nguyễn, Khánh Thuỳ Linh Nguyễn, Thị Nhật Thảo Trần

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2023

Mô tả vật lý: tr.192-199

Bộ sưu tập: Metadata

ID: 339924

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Homalomena pendula have been used in traditional medicine for a long time. This study aimed to investigate the microscopic features of H. pendula and assess its biological activities. The microscopic characteristics were determined by the microscopic method. Acetylcholinesterase inhibitory and antioxidant activities were evaluated by using Ellman method and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging model, respectively. Notably, this is the first report to provide a detailed of the anatomical and powder characteristics of the plant’s leaves and roots. The research revealed that the n-hexane and ethyl acetate extracts of H. pendula exhibited moderate activity in inhibiting acetylcholinesterase and displaying antioxidant properties, with an IC50 value of 133.87 ± 2.76 mg/ml and 69.51 ± 0.05 mg/ml, respectively. Other extracts did not show any notable activity under the study’s experimental conditions. These findings have significant implications for the usage of H. pendula in traditional medicine and highlight its potential as a source of natural compounds with therapeutic properties.Thiên niên kiện lá lớn đã được sử dụng trong y học cổ truyền từ lâu đời. Các đặc điểm vi phẫu và thành phần bột dược liệu của loài này vẫn chưa được mô tả một cách toàn diện. Nghiên cứu này mô tả đặc điểm vi phẫu, soi bột, đánh giá hoạt tính ức chế acetylcholinesterase và hoạt tính chống oxy hoá của loài Thiên niên kiện lá lớn. Nghiên cứu đặc điểm vi học bằng phương pháp kính hiển vi. Hoạt tính ức chế enzyme acetylcholinesterase được đánh giá bằng phương pháp Ellman và chống oxy hóa được thực hiện trên mô hình loại bỏ gốc tự do 2,2-diphenyl-1-picrylhydrazyl (DPPH). Đây là báo cáo đầu tiên về đặc điểm vi phẫu, soi bột của lá và rễ Thiên niên kiện lá lớn. Nghiên cứu đã xác định cao n-hexane thể hiện hoạt tính ức chế acetylcholinesterase trung bình với IC50 là 133,87 ± 2,76 mg/ml. Cao ethyl acetat thể hiện hoạt tính chống oxy hoá trung bình với IC50 là 69,51 ± 0,05 mg/ml. Các cao khác chưa thể hiện hoạt tính ở điều kiện thí nghiệm. Kết quả nghiên cứu đã chứng minh kinh nghiệm sử dụng loài này để làm thuốc của dân gian và là cơ sở khoa học để nghiên cứu, phát triển Thiên niên kiện lá lớn thành nguồn nguyên liệu làm thuốc điều trị các bệnh liên quan đến tác dụng chống oxy hoá và Alzheimer.

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