KẾT QUẢ ĐIỀU TRỊ UNG THƯ VÚ TÁI PHÁT TẠI BỆNH VIỆN TRUNG ƯƠNG THÁI NGUYÊN

0 Người đánh giá. Xếp hạng trung bình 0

Tác giả: Phong Thu Lê, Thị Kim Phượng Trần, Thị Hồng Vũ

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2023

Mô tả vật lý: tr.268-275

Bộ sưu tập: Metadata

ID: 339934

Thêm vào giỏ Liên kết toàn văn

The treatment of cancer recurrence in general as well as breast cancer still faces a number of obstacles due to many problems such as drug resistance, disease characteristics, and toxicity encountered at the initial treatment stage. The study aims to evaluate the results of treatment and some related factors in recurrent breast cancer patients. The study was conducted on 40 patients with recurrent breast cancer treated at Oncology Center of Thai Nguyen National Hospital from 01/01/2019 to 31/12/2021. Patients are mainly treated with chemotherapy. In the chemotherapy group, the rate of response was 28.6%. Patients with invasive carcinoma of no special type, hormone receptor positive, Her-2/neu (-) or 1+ positive had a higher response rate than the group of patients with other histologic types, hormone receptor negative and Her2/neu 3+ (31.0% vs 16.7%
38.9% vs 21.4%
53.8% vs 15.8%)
however, the difference was not statistically significant (p>
0.05). The most common chemotherapy toxicity was grade 1.2. There was no relationship between histologic type, hormone receptor, Her-2/neu expresion, hostologic grade and visceral metastasis status with treatment response rate. Treatment regimens was low toxicity and consistent with the tolerability of the majority of patients.Việc điều trị tái phát ung thư nói chung cũng như ung thư vú nói riêng còn gặp một số trở ngại do các yếu tố như kháng thuốc, đặc điểm bệnh học, độc tính ở giai đoạn điều trị ban đầu. Mục tiêu của nghiên cứu là đánh giá kết quả điều trị và một số yếu tố liên quan ở bệnh nhân ung thư vú tái phát. Nghiên cứu mô tả cắt ngang thực hiện trên 40 bệnh nhân ung thư vú tái phát điều trị tại Trung tâm Ung bướu Bệnh viện Trung ương Thái Nguyên từ ngày 01/01/2019 đến ngày 31/12/2021. Bệnh nhân ung thư vú tái phát chủ yếu được điều trị bằng hóa chất
28,6% có đáp ứng điều trị. Bệnh nhân có mô bệnh học là ung thư biểu mô xâm nhập typ không đặc biệt, thụ thể nội tiết dương tính, Her-2/neu (-) hoặc dương tính 1+ có tỷ lệ đáp ứng cao hơn so với bệnh nhân có thể mô bệnh học khác, thụ thể nội tiết âm tính, Her2/neu 3+ (31,0% so với 16,7%
38,9% so với 21,4%
53,8% so với 15,8%)
sự khác biệt không có ý nghĩa thống kê (p>
0,05). Độc tính của hóa trị hay gặp là độ 1,2. Chưa thấy có mối liên quan giữa các đặc điểm bệnh học với mức độ đáp ứng điều trị
các phác đồ điều trị có độ độc tính thấp, phù hợp với mức độ dung nạp của phần lớn bệnh nhân.

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