ĐÁNH GIÁ TÁC DỤNG HẠ LIPID MÁU CỦA CAO CHIẾT TỪ HẠT CÀ PHÊ XANH (Coffea Canephora Pierre ex A. Froehner) TRỒNG TẠI TỈNH ĐẮK LẮK

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Tác giả: Hoàng Anh Vĩnh Hà, Thị Minh Thu Hoàng, Trung Khoảng Lê, Tố Uyên Nguyễn, Mạnh Hùng Trần

Ngôn ngữ: vie

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Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2023

Mô tả vật lý: tr.369-376

Bộ sưu tập: Báo, Tạp chí

ID: 340134

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Mục tiêu của nghiên cứu là đánh giá độc tính cấp và tác dụng hạ lipid máu của cao chiết từ hạt cà phê xanh (green coffee bean extract - GCBE) trên chuột nhắt trắng. Cao chiết từ hạt cà phê xanh được tiêu chuẩn hóa trước khi thử nghiệm. Thử nghiệm được tiến hành với tác nhân gây tăng lipid máu là tyloxapol (Triton WR 1339), cao chiết được đánh giá ở liều 150 mg/kg và 300 mg/kg trọng lượng chuột. Tác dụng hạ lipid được đánh giá thông qua các chỉ số cholesterol tỷ trọng thấp (LDL), cholesterol tỷ trọng cao (HDL), triglycrerid (TG) và cholesterol toàn phần (TC) trong huyết tương. Với thử nghiệm độc tính cấp, liều gây chết 50% động vật thử nghiệm (LD50) được xác định là 5,24 ± 0,75 g cao/kg chuột. Kết quả các thông số lipid máu cho thấy cao chiết ở liều 150 mg/kg và 300 mg/kg làm giảm LDL, TG và TC so với nhóm bệnh lý (p <
0,05), tác dụng hạ lipid máu của cao cà phê xanh ở liều 300 mg/kg tương đương với atorvastatin 64 mg/kg. Kết quả thực nghiệm trong nghiên cứu này cho thấy cao chiết từ hạt cà phê xanh có thể được sử dụng hỗ trợ điều trị bệnh rối loạn lipid máu.The aim of the study is to evaluate the oral acute toxicity and hypolipidemic effect of green coffee bean extract (GCBE) on Swiss albino mice. The GCBE was standardized before testing. The model of hyperlipidemia in mice was induced by tyloxapol (Triton WR 1339), and the extract was evaluated at doses of 100 mg/kg and 200 mg/kg of body weight. The hypolipidemic effect was evaluated by the level of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and total cholesterol (TC) in serum. For oral acute toxicity, the LD50 of GCBE on mice was 5.24 ± 0.75 g/kg. The results of lipid indices showed that the GCBE at doses of 150 mg/kg and 300 mg/kg reduced LDL-C, TG, and TC compared to the pathological group (p <
0.05). The hypolipidemic effect of GCBE 300 mg/kg was comparable to that of atorvastatin 64 mg/kg. The experimental results of this study suggest that GCBE could be used as an adjunct therapy for the treatment of dyslipidemia.

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