Eclipta prostrata (L.), (Asteraceae), commonly known as Cỏ Mực or Nhọ Nồi in Vietnamese, has been used as a traditional medicine in many countries especially in tropical and sub-tropical regions. Some important pharmacological properties of this plant are analgesic, antioxidant, anti- inflammation, HIV1 (Human immunodeficiency virus 1), anti- tumor, antibacterial, anti- termite etc. Previous reviews indicated the photochemical and pharmaceutical properties of Eclipta spp. while others were on its tissue cultivation. However, many details about the botanical, experimental or research on E. prostrata are limited. Researches on Eclipta spp. mostly focus on the pharmaceutical properties while the biodiversity and biological cultivation is still not marked. Current status of bioactivities, pharmacological profile, biotechnology application, molecular approach, and chloroplast whole genome sequence and their agronomic properties of E. prostrata are covered in this review.