MỐI LIÊN QUAN GIỮA SỰ BIỂU LỘ ĐỒNG THỜI ALDH VÀ KRAS VỚI ĐẶC ĐIỂM MÔ BỆNH HỌC TRONG UNG THƯ DẠ DÀY

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Tác giả: Hồng Thái Dương, Việt An Lê, Phú Hùng Nguyễn

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Khoa học và Công nghệ - Đại học Thái Nguyên, 2023

Mô tả vật lý: tr.465-470

Bộ sưu tập: Metadata

ID: 340544

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Nghiên cứu được tiến hành nhằm phân tích mối liên quan giữa sự biểu lộ đồng thời ALDH và KRAS với đặc điểm mô bệnh học trong ung thư dạ dày. Phương pháp nghiên cứu cắt ngang được thực hiện trên 103 bệnh nhân được chẩn đoán xác định ung thư dạ dày và được phẫu thuật cắt u tại Bệnh viện K. Phân tích mối liên quan giữa sự biểu lộ đồng thời ALDH, KRAS và các đặc điểm mô bệnh học. Kết quả nghiên cứu cho thấy tỷ lệ UTDD ở nam và nữ gặp nhiều nhất ở nhóm tuổi 60-69, chiếm tỷ lệ lần lượt là 34,4% và 35,7%. Sự biểu lộ đồng thời của ALDH và KRAS có tỷ lệ là 71,4%, p <
0,05. Bệnh nhân UTDD biệt hóa thấp có tỷ lệ biểu hiện đồng thời cả 2 dấu ấn cao nhất với 62,0%. Có sự khác biệt về sự biểu hiện đồng thời cả 2 dấu ấn theo độ biệt hóa, p <
0,05. Sự biểu lộ đồng thời ALDH KRAS có mối liên quan đến độ biệt hóa thấp theo mô bệnh học.The study aims to analyze the relationship between the simultaneous expression of ALDH and KRAS with histopathological characteristics in gastric cancer. A cross-sectional study was used on 103 patients with confirmed diagnosis of gastric cancer and surgical resection at K Hospital. The relationship between the simultaneous expression of ALDH, KRAS and other histopathological features was analyzed. Research results showed that the rate of gastric cancer in men and women was most common in the age group 60-69, accounting for 34.4% and 35.7%, respectively. Simultaneous expression of ALDH and KRAS has a rate of 71.4% with p <
0.05. Patients with poorly differentiated gastric cancer had the highest rate of simultaneous expression of both markers with 62.0%. There is a difference in the simultaneous expression of both markers according to the degree of differentiation, p <
0.05. Concurrent expression of ALDH KRAS is associated with low differentiation according to histopathology.

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