Blumea balsamifera (L.) DC. (Asteraceae) has been used as traditional medicine for thousands of years in China and Southeast Asia countries, such as Vietnam, Malaysia, Thailand, and Philippines. The plant displayed various biological activities, such as antitumor, antifungal, radical-scavenging and anti-obesity properties. Our chemical insvestigation of Blumea balsamifera plant collected in Hatinh province led to the isolation of five compounds including cytochalasin H (1), trans-sinapaldehyde (2)and blumeatin A-C (3-5). Their chemical structures were elucidated by NMR, MS spectral analysis and comparison with reported literatures. Compounds cytochalasin H (1) and trans-sinapaldehyde (2) were isolated for the first time from B. balsamifera.